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Note 7 - Stockholders' Equity (Tables)

9 Months Ended

Sep. 30, 2016

Notes Tables

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

		Shares (in thousands)				Weighted- Average Exercise Price				Weighted- Average Remaining Contractual Term (Years)
Balance at January 1, 2016			8,435			$	13.64				7.94
Granted			1,279			$	20.42
Exercised			(653	)		$	8.76
Expired and forfeited			(544	)		$	23.33
Balance at September 30, 2016			8,517			$	14.42				6.86

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		Three Months Ended September 30 ,								Nine Months Ended September 30,
		2016				2015				2016				2015
Research and development		$	3,946			$	927			$	8,347			$	2,652
General and administrative			1,763				1,068				5,229				3,540
Sales and marketing			1,802				826				5,121				2,320
Stock-based compensation expense included in operating expenses		$	7,511			$	2,821			$	18,697			$	8,512
Impact on basic and diluted net loss per share		$	0.19			$	0.08			$	0.50			$	0.27

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		September 30,
		20 16				20 15
Risk-free interest rate			1.5	%			1.7	%
Dividend yield			0.0	%			0.0	%
Volatility			90.6	%			90.7	%
Expected life (years)			6				6

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