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Note 5 - Restructuring (Details Textual) - Restructuring Plan [Member]	3 Months Ended	9 Months Ended
	Sep. 30, 2016 USD ($)	Sep. 30, 2016 USD ($)
Employee Severance [Member]
Restructuring and Related Cost, Expected Cost	$ 3,900,000	$ 3,900,000
Accelerated Non-Cash Stock Option Expense [Member]
Restructuring and Related Cost, Expected Cost	2,600,000	2,600,000
Employee Related Liabilities [Member]
Restructuring and Related Cost, Expected Cost Remaining	1,300,000	1,300,000
Contractual or Lease Obligations or Other Exit Costs [Member]
Restructuring Charges	0	0
Research and Development Expense [Member]
Restructuring Charges	4,700,000	4,700,000
General and Administrative Expense [Member]
Restructuring Charges	400,000	400,000
Selling and Marketing Expense [Member]
Restructuring Charges	100,000	100,000
Accrued Payroll and Employee Liabilities [Member]
Restructuring and Related Cost, Cost Incurred to Date	3,100,000	3,100,000
Restructuring and Related Cost, Expected Cost	$ 6,500,000	6,500,000
Payments for Restructuring		$ 0

X

- Definition

Amount of cash payments made as the result of exit or disposal activities. Excludes payments associated with a discontinued operation or an asset retirement obligation.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)(2)
-URI http://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 25
-URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3536-108585

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Amount of costs incurred to date for the specified restructuring cost.

+ References

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-Topic 420
-SubTopic 10
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-Name Accounting Standards Codification
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-Section S99
-Paragraph 2
-Subparagraph (SAB Topic 5.P.4(b))
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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
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-Paragraph 1
-Subparagraph (b)
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No definition available.

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
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