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Consolidated Statements of Stockholders' Equity (Deficit) - USD ($) $ in Thousands | Note Warrant [Member] Common Stock [Member] | Note Warrant [Member] Additional Paid-in Capital [Member] | Note Warrant [Member] AOCI Attributable to Parent [Member] | Note Warrant [Member] Retained Earnings [Member] | Note Warrant [Member] | Common Stock [Member] | Additional Paid-in Capital [Member] | AOCI Attributable to Parent [Member] | Retained Earnings [Member] | Total
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2013 |  |  |  |  |  | 23,572,000 |  |  |  |
Balance at Dec. 31, 2013 |  |  |  |  |  | $ 237 | $ 307,578 |  | $ (238,870) | $ 68,945
Issuance of common stock and pre-funded warrants in a public offering, net (in shares) | 4,751,000 |  |  |  |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in a public offering, net | $ 47 | $ 58,869 |  |  | $ 58,916 |  |  |  |  |
Conversion benefit included in Convertible Notes issued |  |  |  |  |  |  | 309 |  |  | 309
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  |  | 12,000 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan |  |  |  |  |  |  | 91 |  |  | $ 91
Issuance of common stock upon exercise of stock options (in shares) |  |  |  |  |  | 588,000 |  |  |  | 756,593
Issuance of common stock upon exercise of stock options |  |  |  |  |  | $ 5 | 3,096 |  |  | $ 3,101
Issuance of common stock upon exercise of warrants (in shares) | 304,000 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants | $ 3 | (3) |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  |  | 8,067 |  |  | 8,067
Net loss |  |  |  |  |  |  |  |  | (76,367) | (76,367)
Balance (in shares) at Dec. 31, 2014 |  |  |  |  |  | 29,227,000 |  |  |  |
Balance at Dec. 31, 2014 |  |  |  |  |  | $ 292 | 378,007 |  | (315,237) | 63,062
Net unrealized loss on short-term investments |  |  |  |  |  |  |  |  |  |
Comprehensive loss |  |  |  |  |  |  |  |  |  | (76,367)
Conversion benefit included in Convertible Notes issued |  |  |  |  |  |  | 328 |  |  | 328
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  |  | 31,000 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan |  |  |  |  |  |  | 257 |  |  | $ 257
Issuance of common stock upon exercise of stock options (in shares) |  |  |  |  |  | 1,042,000 |  |  |  | 1,042,343
Issuance of common stock upon exercise of stock options |  |  |  |  |  | $ 11 | 9,524 |  |  | $ 9,535
Issuance of common stock upon exercise of warrants (in shares) | 286,000 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants | $ 3 | (3) |  |  |  | 55 | 128,144 |  |  | 128,199
Stock-based compensation expense |  |  |  |  |  |  | 14,360 |  |  | 14,360
Net loss |  |  |  |  |  |  |  |  | (97,591) | (97,591)
Balance (in shares) at Dec. 31, 2015 |  |  |  |  |  | 36,106,000 |  |  |  |
Balance at Dec. 31, 2015 |  |  |  |  |  | $ 361 | 530,617 | (40) | (412,828) | 118,110
Issuance of common stock in a public offering, net (in shares) |  |  |  |  |  | 5,520,000 |  |  |  |
Net unrealized loss on short-term investments |  |  |  |  |  |  |  | (40) |  | (40)
Comprehensive loss |  |  |  |  |  |  |  |  |  | (97,631)
Conversion benefit included in Convertible Notes issued |  |  |  |  |  |  | 348 |  |  | 348
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  |  | 55,000 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan |  |  |  |  |  | $ 1 | 770 |  |  | $ 771
Issuance of common stock upon exercise of stock options (in shares) |  |  |  |  |  | 798,000 |  |  |  | 798,363
Issuance of common stock upon exercise of stock options |  |  |  |  |  | $ 8 | 6,676 |  |  | $ 6,684
Issuance of common stock upon exercise of warrants (in shares) | 2,396,000 |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants | $ 24 | $ (24) |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  |  | 25,956 |  |  | 25,956
Net loss |  |  |  |  |  |  |  |  | (173,143) | (173,143)
Balance (in shares) at Dec. 31, 2016 |  |  |  |  |  | 39,355,000 |  |  |  |
Balance at Dec. 31, 2016 |  |  |  |  |  | $ 394 | 564,343 | (17) | (585,971) | (21,251)
Net unrealized loss on short-term investments |  |  |  |  |  |  |  | 23 |  | 23
Comprehensive loss |  |  |  |  |  |  |  |  |  | $ (173,120)

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