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Note 4 - Balance Sheet Details (Tables) | 12 Months Ended
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Dec. 31, 2016
Notes Tables |
Available-for-sale Securities [Table Text Block] |
|  | December 31, 201 6 |
|  |  |  |  |  | Gross |  |  | Gross |  |  |  |  |
|  | Amortized |  |  | Unrealized |  |  | Unrealized |  |  | Estimated |
|  | Cost |  |  | Gains |  |  | Losses |  |  | Fair Value |
United States corporate debt |  | $ | 12,048 |  |  | $ | — |  |  | $ | (9 | ) |  | $ | 12,039 |
Foreign corporate debt |  |  | 14,065 |  |  |  | — |  |  |  | (8 | ) |  |  | 14,057 |
United States commercial paper |  |  | 8,635 |  |  |  | — |  |  |  | — |  |  |  | 8,635 |
Foreign commercial paper |  |  | 2,993 |  |  |  | — |  |  |  | — |  |  |  | 2,993 |
Total |  | $ | 37,741 |  |  | $ | — |  |  | $ | (17 | ) |  | $ | 37,724 |
|  | December 31, 201 5 |
|  |  |  |  |  | Gross |  |  | Gross |  |  |  |  |
|  | Amortized |  |  | Unrealized |  |  | Unrealized |  |  | Estimated |
|  | Cost |  |  | Gains |  |  | Losses |  |  | Fair Value |
United States corporate debt |  | $ | 27,750 |  |  | $ | — |  |  | $ | (35 | ) |  | $ | 27,715 |
Foreign corporate debt |  |  | 4,927 |  |  |  | — |  |  |  | (5 | ) |  |  | 4,922 |
United States commercial paper |  |  | 7,770 |  |  |  | — |  |  |  | — |  |  |  | 7,770 |
Foreign commercial paper |  |  | 15,579 |  |  |  | — |  |  |  | — |  |  |  | 15,579 |
Total |  | $ | 56,026 |  |  | $ | — |  |  | $ | (40 | ) |  | $ | 55,986 |
Schedule of Inventory, Current [Table Text Block] |
|  | December 31, |
|  | 2016 |  |  | 2015 |
Raw materials |  | $ | 1,647 |  |  | $ | — |
Work in process |  |  | 1,104 |  |  |  | — |
Finished goods |  |  | 2,589 |  |  |  | — |
Total inventory |  | $ | 5,340 |  |  | $ | — |
Property, Plant and Equipment [Table Text Block] |
|  | December 31, |
|  | 2016 |  |  | 2015 |
Scientific equipment |  | $ | 7,952 |  |  | $ | 5,593 |
Computer equipment and software |  |  | 1,429 |  |  |  | 1,272 |
Furniture, fixtures and office equipment |  |  | 674 |  |  |  | 352 |
Leasehold improvements |  |  | 1,635 |  |  |  | 1,384 |
Property and equipment |  |  | 11,690 |  |  |  | 8,601 |
Less: accumulated depreciation and amortization |  |  | (6,614 | ) |  |  | (5,552 | )
Property and equipment, net |  | $ | 5,076 |  |  | $ | 3,049 |
Schedule of Accrued Liabilities [Table Text Block] |
|  | December 31, |
|  | 20 16 |  |  | 2015 |
Accrued employee salaries and benefits |  | $ | 2,236 |  |  | $ | 1,863 |
Accrued bonuses |  |  | 3,474 |  |  |  | 2,965 |
Accrued expenses for realignment (see Note 6) |  |  | 2,704 |  |  |  | — |
Total accrued payroll and employee liabilities |  | $ | 8,414 |  |  | $ | 4,828 |
|  | December 31, |
|  | 2016 |  |  | 2015 |
Accrued consulting and professional fees |  | $ | 4,703 |  |  | $ | 3,914 |
Accrued accounts payable |  |  | 1,039 |  |  |  | 36 |
Accrued sales allowances |  |  | 342 |  |  |  | — |
Deferred rent |  |  | 116 |  |  |  | 61 |
Other accrued liabilities |  |  | 88 |  |  |  | 143 |
Total other accrued liabilities |  | $ | 6,288 |  |  | $ | 4,154 |

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