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v3.6.0.2

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Operating activities: |  |  |
Net loss | $ (173,143) | $ (97,591) | $ (76,367)
Adjustments to reconcile net loss to net cash used for operating activities: |  |  |
Stock-based compensation expense | 25,956 | 14,360 | 8,067
Depreciation and amortization | 1,099 | 734 | 578
Amortization of Debt Discount (Premium) | 689 | 624 | 573
Impairment loss on property and equipment | 0 | 0 | 905
Loss (gain) on disposal of property and equipment | 9 | (118) | 17
Amortization of premium on short-term investments | 274 | 89 |
Change in operating assets and liabilities: |  |  |
Accounts receivable | (1,960) |  |
Prepaid expenses and other current assets | (338) | (2,443) | (419)
Inventory | (5,340) |  |
Accounts payable | 3,514 | 751 | 1,285
Accrued clinical liabilities | 7,976 | 1,420 | 2,038
Accrued payroll and employee liabilities | 3,586 | 2,097 | 165
Deferred revenue | 1,099 |  |
Other accrued liabilities | 2,482 | 1,551 | 2,876
Net cash used for operating activities | (134,097) | (78,526) | (60,282)
Investing activities: |  |  |
Purchases of short-term investments | (43,318) | (56,115) |
Maturities of short-term investments | 61,329 |  |
Purchases of property and equipment | (3,135) | (1,086) | (1,438)
Proceeds from the sale of property and equipment |  | 241 |
Net cash provided by (used for) investing activities | 14,876 | (56,960) | (1,438)
Financing activities: |  |  |
Net proceeds from sale of common stock and/or pre-funded warrants |  | 128,199 | 58,916
Proceeds from purchases under the Employee Stock Purchase Plan | 771 | 257 | 91
Proceeds from stock option exercises | 6,684 | 9,535 | 3,101
Proceeds from issuance of promissory note payable to related party | 50,000 |  |
Net cash provided by financing activities | 57,455 | 137,991 | 62,108
Net (decrease) increase in cash and cash equivalents | (61,766) | 2,505 | 388
Cash and cash equivalents at beginning of year | 75,180 | 72,675 | 72,287
Cash and cash equivalents at end of year | 13,414 | 75,180 | 72,675
Supplemental disclosure of cash flow information: |  |  |
Interest paid | $ 1,622 |  |

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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- References No definition available. + Details
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