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Note 8 - Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2016

Notes Tables

Common Stock Reserved for Future Issuance [Table Text Block]

		Number of Shares
Stock options outstanding			11,845,376
Stock options available for grant			2,653,548
Employee stock purchase plan			144,600
Warrants outstanding			600,000
Shares of common stock underlying Convertible Notes outstanding (see Note 7)			7,521,416
Total shares reserved for future issuance			22,764,940

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

		Outstanding Options
						Weighted-
						Average
		Number of				Exercise
		Shares				Price
Balance at December 31, 2013			6,355,681			$	8.22
Granted			3,181,001				9.40
Exercised			(756,593	)			6.34
Cancelled			(862,085	)			9.88
Balance at December 31, 2014			7,918,004				8.69
Granted			2,134,505				28.95
Exercised			(1,042,343	)			9.15
Cancelled			(575,178	)			10.42
Balance at December 31, 2015			8,434,988				13.64
Granted			4,920,661				15.98
Exercised			(798,363	)			8.37
Cancelled			(711,910	)			22.43
Balance at December 31, 2016			11,845,376			$	14.44

Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding and Exercisable [Table Text Block]

		Years Ended December 31,
		2016								2015								2014
						Weighted-								Weighted-								Weighted-
						Average								Average								Average
						Exercise								Exercise								Exercise
		Options				Price				Options				Price				Options				Price
Exercisable at end of year			4,356,665			$	11.66				2,587,392			$	8.72				2,237,901			$	9.01
Options vested or expected to vest			11,234,529			$	14.32				8,059,481			$	13.38				7,841,074			$	8.69

Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]

																					Weighted-
									Weighted-												Average
									Average				Weighted-								Exercise
									Remaining				Average								Price of
Options			Range of						Contractual				Exercise				Options				Options
Outstanding			Exercise Prices						Life (in years)				Price				Exercisable				Exercisable
581,518				$3.80	–	7.00				1.01			$	6.02				581,518			$	6.02
1,935,473					$7.20					6.28				7.20				1,054,143				7.20
1,793,013				$7.61	–	9.05				7.09				8.93				1,104,899				8.94
843,387				$9.20	–	12.65				4.23				10.33				736,434				10.39
2,271,111					$13.00					9.97				13.00				—				—
548,025				$13.20	–	16.62				7.38				15.46				202,650				14.57
1,241,350					$16.83					9.71				16.83				51,320				16.83
1,226,884				$17.10	–	28.30				8.41				22.48				164,692				26.76
1,203,272				$28.73	–	29.86				8.49				29.44				395,686				29.44
201,343				$29.95	–	102.40				8.61				34.78				65,323				35.03
11,845,376				$3.80	–	102.40				7.60				14.44				4,356,665				11.66

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		December 31,
		2016				2015				2014
Research and development		$	11,316			$	4,701			$	3,329
General and administrative			7,402				6,282				2,532
Sales and marketing			7,238				3,377				2,206
Stock-based compensation expense included in operating expenses		$	25,956			$	14,360			$	8,067

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		December 31,
		2016				2015				2014
Risk-free interest rate			1.7	%			1.7	%			1.9	%
Dividend yield			—	%			—	%			—	%
Volatility			89.1	%			92.7	%			99.0	%
Expected life (years)			6				6				6

		December 31,
		2016				2015				2014
Risk-free interest rate			0.4	%			0.1	%			0.1	%
Dividend yield			—	%			—	%			—	%
Volatility			68.3	%			86.7	%			53.8	%
Expected life (months)			6				6				6

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