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Note 11 - Summary of Quarterly Consolidated Financial Data (unaudited) (Tables)
 12 Months Ended
Dec. 31, 2016
Notes Tables  
Quarterly Financial Information [Table Text Block]
 
 
2016
 
 
 
First
Quarter
 
 
Second
Quarter
 
 
Third
Quarter
 
 
Fourth
Quarter
 
 
 
(In thousands, except per share amounts)
 
Revenues:
                                
Net product sales
   $
—
     $
—
     $
—
     $
1,279
  
Operating expenses:
                                
Cost of product sales
    
—
      
—
      
—
      
35
  
Research and development
    
16,092
      
27,286
      
30,242
      
29,505
  
General and administrative
    
5,367
      
4,774
      
5,333
      
5,892
  
Sales and marketing
    
11,853
      
11,006
      
12,159
      
12,650
  
Loss from operations
    
(33,312
)
    
(43,066
)
    
(47,734
)
    
(46,803
)
Interest income
    
118
      
97
      
111
      
119
  
Interest expense
    
(251
)
    
(257
)
    
(886
)
    
(1,270
)
Other expense
    
—
      
—
      
—
      
(9
)
Net loss
   $
(33,445
)
   $
(43,226
)
   $
(48,509
)
   $
(47,963
)
Basic and diluted net loss per share
   $
(0.92
)
   $
(1.17
)
   $
(1.24
)
   $
(1.22
)
 
 
2015
 
 
 
First
Quarter
 
 
Second
Quarter
 
 
Third
Quarter
 
 
Fourth
Quarter
 
 
 
(In thousands, except per share amounts)
 
Operating expenses:
                                
Research and development
   $
14,504
     $
16,175
     $
14,241
     $
16,263
  
General and administrative
    
3,587
      
4,082
      
4,127
      
6,599
  
Sales and marketing
    
2,269
      
2,757
      
4,123
      
8,198
  
Loss from operations
    
(20,360
)
    
(23,014
)
    
(22,491
)
    
(31,060
)
Interest income
    
22
      
26
      
61
      
65
  
Interest expense
    
(232
)
    
(237
)
    
(242
)
    
(247
)
Other income
    
—
      
118
      
—
      
—
  
Net loss
   $
(20,570
)
   $
(23,107
)
   $
(22,672
)
   $
(31,242
)
Basic and diluted net loss per share
   $
(0.70
)
   $
(0.74
)
   $
(0.63
)
   $
(0.87
)