XML 16 R4.htm IDEA: XBRL DOCUMENT v3.6.0.2
Consolidated Statements of Comprehensive Loss - USD ($)
shares in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenues:      
Net product sales $ 1,279,000
Operating expenses:      
Cost of product sales 35,000
Research and development 103,125,000 61,183,000 54,833,000
General and administrative 21,366,000 18,395,000 11,020,000
Sales and marketing 47,668,000 17,347,000 8,708,000
Total operating expenses 172,194,000 96,925,000 74,561,000
Loss from operations (170,915,000) (96,925,000) (74,561,000)
Other expense, net:      
Interest expense (2,664,000) (958,000) (887,000)
Other income (expense) 436,000 292,000 (919,000)
Total other expense, net (2,228,000) (666,000) (1,806,000)
Net loss (173,143,000) (97,591,000) (76,367,000)
Unrealized gains (losses) on short-term investments 23,000 (40,000)
Comprehensive loss $ (173,120,000) $ (97,631,000) $ (76,367,000)
Basic and diluted net loss per share (in dollars per share) $ (4.56) $ (2.95) $ (2.87)
Shares used in computing basic and diluted net loss per share (in shares) 37,925 33,081 26,569