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Note 8 - Stockholders' Equity (Details Textual) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended											12 Months Ended			109 Months Ended
	Dec. 01, 2007	Jan. 31, 2017	Jun. 30, 2016	Jun. 30, 2015	May 31, 2015	May 30, 2015	Jun. 30, 2014	May 31, 2014	May 30, 2014	Jun. 30, 2011	May 31, 2010	May 30, 2009	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2016	Dec. 31, 2007
Class of Warrant or Right, Number of Securities Called by Warrants or Rights													600,000			600,000
Proceeds from Issuance or Sale of Equity														$ 128,199	$ 58,916
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price													$ 8.37	$ 9.15	$ 6.34
Common Stock, Shares, Issued													39,355,000	36,106,000		39,355,000
Common Stock, Capital Shares Reserved for Future Issuance													22,764,940			22,764,940
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant													2,653,548			2,653,548
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period													10 years
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period													4 years
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period													798,363	1,042,343	756,593
Proceeds from Stock Options Exercised													$ 6,684	$ 9,535	$ 3,101
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period													707,617
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price													$ 22.35
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period													4,293
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price													$ 35.09
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term													5 years 109 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value													$ 10,400	13,900
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value													$ 16,900	$ 46,600		$ 16,900
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Outstanding Options													11,845,376			11,845,376
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized													$ 86,400			$ 86,400
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition													2 years 328 days
Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized	5,000		100,000			100,000			25,000	25,000		10,000				275,000
Share-based Compensation Arrangement by Share-based Payment Award Maximum Employee Earnings with held to Purchase Common Stock Percent													10.00%
Share-based Compensation Arrangement by Share-based Payment Award Discount on Stock Price													85.00%
Share-based Compensation Arrangement by Share-based Payment Award Eligible Participants Percent													51.00%
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period													54,932	30,361	12,028
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price													$ 14.03	$ 8.46	$ 7.59
Common Stock, Shares, Issued													130,400			130,400
Common Stock, Capital Shares Reserved for Future Issuance													144,600			144,600
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value													$ 11.82	21.92	7.40
Share-based Compensation Arrangement by Share-based Payment Award, Per Share Weighted-average Fair Value Price of Shares Purchased													$ 6.10	$ 8.23	$ 3.06	$ 6.10
Equity Incentive Plan 2007 [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized			3,000,000		4,300,000			1,750,000		4,500,000	100,000		13,800,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized																	150,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant													2,653,548			2,653,548
Private Placement 2011 [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights										4,000,000
Class of Warrant or Right, Exercise Price of Warrants or Rights										$ 3.60
Subsequent Event [Member]
Proceeds from Issuance of Common Stock		$ 163,700
Pre-funded Warrants[Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights							600,000
Share Price							$ 11.74
Class of Warrant or Right, Exercise Price of Warrants or Rights							$ 0.01
Common Stock [Member]
Stock Issued During Period, Shares, New Issues				5,500,000			4,800,000
Sale of Stock, Price Per Share				$ 24.75			$ 11.75
Proceeds from Issuance or Sale of Equity				$ 128,200
Payments of Stock Issuance Costs				$ 8,400
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period													798,000	1,042,000	588,000
Common Stock [Member] | Private Placement 2011 [Member]
Stock Issued During Period, Shares, New Issues													2,395,700	285,713	303,614
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Exercised													2,965,477	343,813	460,706
Common Stock [Member] | Subsequent Event [Member]
Stock Issued During Period, Shares, New Issues		14,100,000
Share Price		$ 12.20
Payments of Stock Issuance Costs		$ 8,800
Common Stock and Prefunded Warrants [Member]
Proceeds from Issuance or Sale of Equity							$ 58,900
Payments of Stock Issuance Costs							$ 4,000

X

- Definition

The purchase price of stock from 1997 Employee Stock Purchase Plan will be the lower of the closing price of common stock on: (i) the first trading day in the enrollment period, as defined in the Purchase Plan, in which the purchase is made, or (ii) the purchase date.

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Percent of eligible employees that participated in the 1997 Employee Stock Purchase Plan.

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Maximum percent employees can elect to withhold from their base earnings to purchase common stock.

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The weighted average fair value of per share prices paid for shares purchased on the open market for issuance to employees under the plan.

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Exercise price per share or per unit of warrants or rights outstanding.

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Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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Aggregate number of common shares reserved for future issuance.

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Total number of common shares of an entity that have been sold or granted to shareholders (includes common shares that were issued, repurchased and remain in the treasury). These shares represent capital invested by the firm's shareholders and owners, and may be all or only a portion of the number of shares authorized. Shares issued include shares outstanding and shares held in the treasury.

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Unrecognized cost of unvested share-based compensation awards.

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Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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The cash outflow for cost incurred directly with the issuance of an equity security.

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The cash inflow from the additional capital contribution to the entity.

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The cash inflow from the issuance of common stock, preferred stock, treasury stock, stock options, and other types of equity.

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The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately.

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Per share amount received by subsidiary or equity investee for each share of common stock issued or sold in the stock transaction.

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Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Number of non-option equity instruments exercised by participants.

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Number of additional shares authorized for issuance under an established share-based compensation plan.

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The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested).

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares.

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Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of share instruments newly issued under a share-based compensation plan.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options of the plan that expired.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.

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The number of shares reserved for issuance pertaining to the outstanding stock options as of the balance sheet date for all option plans in the customized range of exercise prices.

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Price of a single share of a number of saleable stocks of a company.

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Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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