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Note 9 - Income Taxes (Details Textual) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Income Tax Expense (Benefit) $ 0 $ 0 $ 0
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount 55,200 40,400  
Deferred Tax Assets, Tax Credit Carryforwards, Research 16,687 11,181  
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued 0 0  
Unrecognized Tax Benefits 100 100  
Unrecognized Tax Benefits that Would Impact Effective Tax Rate 100 $ 100  
Domestic Tax Authority [Member]      
Operating Loss Carryforwards 387,600    
Deferred Tax Assets, Tax Credit Carryforwards, Research 11,600    
Domestic Tax Authority [Member] | Stock Compensation Plan [Member]      
Operating Loss Carryforwards 10,000    
State and Local Jurisdiction [Member]      
Operating Loss Carryforwards 268,500    
Deferred Tax Assets, Tax Credit Carryforwards, Research 7,600    
State and Local Jurisdiction [Member] | Stock Compensation Plan [Member]      
Operating Loss Carryforwards $ 4,200