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Consolidated Statements of Stockholders' Equity (Deficit) - USD ($)
$ in Thousands
Note Warrant [Member]
Common Stock [Member]
Note Warrant [Member]
Additional Paid-in Capital [Member]
Note Warrant [Member]
AOCI Attributable to Parent [Member]
Note Warrant [Member]
Retained Earnings [Member]
Note Warrant [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
AOCI Attributable to Parent [Member]
Retained Earnings [Member]
Total
Balance (in shares) at Dec. 31, 2013           23,572,000        
Balance at Dec. 31, 2013           $ 237 $ 307,578 $ (238,870) $ 68,945
Issuance of common stock and pre-funded warrants in a public offering, net (in shares) 4,751,000                  
Issuance of common stock and pre-funded warrants in a public offering, net $ 47 $ 58,869 $ 58,916          
Conversion benefit included in Convertible Notes issued           309 309
Issuance of common stock under Employee Stock Purchase Plan (in shares)           12,000        
Issuance of common stock under Employee Stock Purchase Plan           91 $ 91
Issuance of common stock upon exercise of stock options (in shares)           588,000       756,593
Issuance of common stock upon exercise of stock options           $ 5 3,096 $ 3,101
Issuance of common stock upon exercise of warrants (in shares) 304,000                  
Issuance of common stock upon exercise of warrants $ 3 (3)          
Stock-based compensation expense           8,067 8,067
Net loss           (76,367) (76,367)
Balance (in shares) at Dec. 31, 2014           29,227,000        
Balance at Dec. 31, 2014           $ 292 378,007 (315,237) 63,062
Net unrealized loss on short-term investments                  
Comprehensive loss                   (76,367)
Conversion benefit included in Convertible Notes issued           328 328
Issuance of common stock under Employee Stock Purchase Plan (in shares)           31,000        
Issuance of common stock under Employee Stock Purchase Plan           257 $ 257
Issuance of common stock upon exercise of stock options (in shares)           1,042,000       1,042,343
Issuance of common stock upon exercise of stock options           $ 11 9,524 $ 9,535
Issuance of common stock upon exercise of warrants (in shares) 286,000                  
Issuance of common stock upon exercise of warrants $ 3 (3) 55 128,144 128,199
Stock-based compensation expense           14,360 14,360
Net loss           (97,591) (97,591)
Balance (in shares) at Dec. 31, 2015           36,106,000        
Balance at Dec. 31, 2015           $ 361 530,617 (40) (412,828) 118,110
Issuance of common stock in a public offering, net (in shares)           5,520,000        
Net unrealized loss on short-term investments           (40) (40)
Comprehensive loss           (97,631)
Conversion benefit included in Convertible Notes issued           348 348
Issuance of common stock under Employee Stock Purchase Plan (in shares)           55,000        
Issuance of common stock under Employee Stock Purchase Plan           $ 1 770 $ 771
Issuance of common stock upon exercise of stock options (in shares)           798,000       798,363
Issuance of common stock upon exercise of stock options           $ 8 6,676 $ 6,684
Issuance of common stock upon exercise of warrants (in shares) 2,396,000                  
Issuance of common stock upon exercise of warrants $ 24 $ (24)          
Stock-based compensation expense           25,956 25,956
Net loss           (173,143) (173,143)
Balance (in shares) at Dec. 31, 2016           39,355,000        
Balance at Dec. 31, 2016           $ 394 564,343 (17) (585,971) (21,251)
Net unrealized loss on short-term investments           23 23
Comprehensive loss           $ (173,120)