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Condensed Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Revenues:    
Net product sales $ 3,632
Operating expenses:    
Cost of product sales 1,186
Research and development 33,384 16,092
General and administrative 6,742 5,367
Sales and marketing 11,619 11,853
Total operating expenses 52,931 33,312
Loss from operations (49,299) (33,312)
Interest expense, net (1,030) (133)
Net loss (50,329) (33,445)
Other comprehensive loss:    
Unrealized gains (losses) on short-term investments (13) 41
Comprehensive loss $ (50,342) $ (33,404)
Basic and diluted net loss per share (in dollars per share) $ (1) $ (0.92)
Shares used in computing basic and diluted net loss per share (in shares) 50,530 36,229