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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Operating activities:    
Net loss $ (50,329) $ (33,445)
Adjustments to reconcile net loss to net cash used for operating activities:    
Stock-based compensation expense 8,021 5,355
Depreciation and amortization 329 238
Amortization of debt discount 185 166
Loss on disposal of property and equipment 5
(Accretion of discount) amortization of premium on short-term investments (13) 145
Change in operating assets and liabilities:    
Accounts receivable (8,367)
Prepaid expenses and other current assets 274 (1,420)
Inventory 699 (2,744)
Accounts payable (2,337) 3,561
Accrued clinical liabilities (1,983) (1,496)
Accrued payroll and employee liabilities (2,292) (1,859)
Deferred revenue 4,136
Other accrued liabilities 1,091 (852)
Net cash (used for) provided by operating activities (50,581) (32,351)
Investing activities:    
Purchases of short-term investments (69,374)
Maturities of short-term investments 25,395 23,491
Purchases of property and equipment (938) (834)
Net cash (used for) provided by investing activities (44,917) 22,657
Financing activities:    
Net proceeds from sale of common stock 163,747
Proceeds from stock option exercises 1,850 2,530
Net cash provided by financing activities 165,597 2,530
Net increase (decrease) in cash and cash equivalents 70,099 (7,164)
Cash and cash equivalents at beginning of year 13,414 75,180
Cash and cash equivalents at end of year 83,513 68,016
Supplemental disclosure of cash flow information:    
Interest paid $ 1,000