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Note 5 - Realignment of Goals and Objectives and New Development Focus (Details Textual) $ in Millions	3 Months Ended	9 Months Ended	12 Months Ended
	Sep. 30, 2017 USD ($)	Sep. 30, 2017 USD ($)	Sep. 30, 2017 USD ($)
Restructuring and Related Cost, Expected Cost	$ 9.9	$ 9.9	$ 9.9
Restructuring Plan [Member]
Restructuring Charges		1.9	9.7
Payments for Restructuring		4.5
Restructuring Plan [Member] | Research and Development Expense [Member]
Restructuring Charges	0.2	1.6
Restructuring Plan [Member] | General and Administrative Expense [Member]
Restructuring Charges		0.3
Restructuring Plan [Member] | Employee Severance [Member]
Restructuring and Related Cost, Expected Cost	6.0	6.0	6.0
Restructuring Plan [Member] | Accelerated Non-Cash Stock Option Expense [Member]
Restructuring and Related Cost, Expected Cost	3.9	3.9	3.9
Restructuring Plan [Member] | Employee Related Liabilities [Member]
Restructuring and Related Cost, Expected Cost Remaining	$ 0.2	$ 0.2	$ 0.2

X

- Definition

Amount of cash payments made as the result of exit or disposal activities. Excludes payments associated with a discontinued operation or an asset retirement obligation.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)(2)
-URI http://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 25
-URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3536-108585

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- Definition

Amount expected to be recognized in earnings for the specified restructuring cost.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
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Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SAB Topic 5.P.4(b))
-URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140904-122747

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 5.P.3)
-URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140864-122747

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-URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585

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-Name Accounting Standards Codification
-Topic 420
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-Section 50
-Paragraph 1
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-URI http://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869

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