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Condensed Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues:
Net product sales	$ 8,572		$ 20,714
Operating expenses:
Cost of product sales	1,051		3,250
Research and development	28,844	30,242	90,825	73,620
General and administrative	6,462	5,333	19,389	15,474
Sales and marketing	13,529	12,159	39,918	35,018
Total operating expenses	49,886	47,734	153,382	124,112
Loss from operations	(41,314)	(47,734)	(132,668)	(124,112)
Interest expense, net	(552)	(775)	(2,326)	(1,068)
Net loss	(41,866)	(48,509)	(134,994)	(125,180)
Other comprehensive income (loss):
Unrealized gains (losses) on short-term investments		(16)	11	23
Comprehensive loss	$ (41,866)	$ (48,525)	$ (134,983)	$ (125,157)
Basic and diluted net loss per share (in dollars per share)	$ (0.77)	$ (1.24)	$ (2.55)	$ (3.34)
Shares used in computing basic and diluted net loss per share (in shares)	54,176	39,113	52,846	37,470

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Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.

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Total costs related to goods produced and sold during the reporting period.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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