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v3.8.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Operating activities: |  |  |
Net loss | $ (197,484) | $ (173,143) | $ (97,591)
Adjustments to reconcile net loss to net cash used for operating activities: |  |  |
Stock-based compensation expense | 30,538 | 25,956 | 14,360
Depreciation and amortization | 1,531 | 1,099 | 734
Amortization of debt discount | 773 | 689 | 624
Loss (gain) on disposal of property and equipment | 39 | 9 | (118)
(Accretion of discount) amortization of premium on short-term investments | (278) | 274 | 89
Change in operating assets and liabilities: |  |  |
Accounts receivable | (39,914) | (1,960) |
Prepaid expenses and other current assets | 3 | (338) | (2,443)
Inventory | (4,768) | (5,340) |
Accounts payable | 11,955 | 3,514 | 751
Accrued clinical liabilities | 13,713 | 7,976 | 1,420
Accrued payroll and employee liabilities | 446 | 3,586 | 2,097
Deferred revenue | 1,664 | 1,099 |
Other accrued liabilities | 11,482 | 2,482 | 1,551
Net cash used for operating activities | (170,300) | (134,097) | (78,526)
Investing activities: |  |  |
Purchases of short-term investments | (121,570) | (43,318) | (56,115)
Maturities of short-term investments | 131,783 | 61,329 |
Purchases of property and equipment | (2,553) | (3,135) | (1,086)
Proceeds from the sale of property and equipment | 78 |  | 241
Net cash provided by (used for) investing activities | 7,738 | 14,876 | (56,960)
Financing activities: |  |  |
Net proceeds from sale of common stock and/or pre-funded warrants | 306,279 |  | 128,199
Proceeds from purchases under the Employee Stock Purchase Plan | 989 | 771 | 257
Proceeds from stock option exercises | 11,463 | 6,684 | 9,535
Proceeds from issuance of promissory note payable to related party |  | 50,000 |
Repayment of promissory note payable to related party | (25,000) |  |
Net cash provided by financing activities | 293,731 | 57,455 | 137,991
Net increase (decrease) in cash and cash equivalents | 131,169 | (61,766) | 2,505
Cash and cash equivalents at beginning of year | 13,414 | 75,180 | 72,675
Cash and cash equivalents at end of year | 144,583 | 13,414 | 75,180
Supplemental disclosure of cash flow information: |  |  |
Interest paid | $ 2,789 | $ 1,622 |

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
Name: | us-gaap_ShareBasedCompensation
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- References No definition available. + Details
Name: | us-gaap_SupplementalCashFlowInformationAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration