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Note 11 - Summary of Quarterly Consolidated Financial Data (Unaudited) - Summary Quarterly Results of Operations (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenues: |  |  |  |  |  |  |  |  |  |  |
Net product sales | $ 10,053 | $ 8,572 | $ 8,510 | $ 3,632 | $ 1,279 |  |  |  | $ 30,767 | $ 1,279 |
Cost of product sales | (1,338) | (1,051) | (1,013) | (1,186) | (35) |  |  |  | (4,588) | (35) |
Gross Profit | 8,715 | 7,521 | 7,497 | 2,446 | 1,244 |  |  |  |  |  |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |
Research and development | 47,757 | 28,844 | 28,597 | 33,384 | 29,505 | 30,242 | 27,286 | 16,092 | 138,582 | 103,125 | 61,183
General and administrative | 6,165 | 6,462 | 6,185 | 6,742 | 5,892 | 5,333 | 4,774 | 5,367 | 25,554 | 21,366 | 18,395
Sales and marketing | 16,683 | 13,529 | 14,770 | 11,619 | 12,650 | 12,159 | 11,006 | 11,853 | 56,601 | 47,668 | 17,347
Loss from operations | (61,890) | (41,314) | (42,055) | (49,299) | (46,803) | (47,734) | (43,066) | (33,312) |  |  |
Other expense, net | (600) | (552) | (744) | (1,030) | (1,160) | (775) | (160) | (133) | (38) | (9) | 118
Net loss | $ (62,490) | $ (41,866) | $ (42,799) | $ (50,329) | $ (47,963) | $ (48,509) | $ (43,226) | $ (33,445) | $ (197,484) | $ (173,143) | $ (97,591)
Basic and diluted net loss per share (in dollars per share) | $ (1.09) | $ (0.77) | $ (0.80) | $ (1) | $ (1.22) | $ (1.24) | $ (1.17) | $ (0.92) | $ (3.65) | $ (4.56) | $ (2.95)

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- Definition Total costs related to goods produced and sold during the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.2(a)) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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