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Note 4 - Balance Sheet Details (Tables) | 12 Months Ended
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Dec. 31, 2017
Notes Tables |
Available-for-sale Securities [Table Text Block] |
|  | December 31, 201 7 |
|  | Amortized Cost |  |  | Gross Unrealized Gains |  |  | Gross Unrealized Losses |  |  | Estimated Fair Value |
U.S. corporate debt securities |  | $ | 13,003 |  |  | $ | — |  |  | $ | (10 | ) |  | $ | 12,993 |
U.S. commercial paper |  |  | 4,929 |  |  |  | — |  |  |  | — |  |  |  | 4,929 |
Foreign commercial paper |  |  | 9,874 |  |  |  | — |  |  |  | — |  |  |  | 9,874 |
Total |  | $ | 27,806 |  |  | $ | — |  |  | $ | (10 | ) |  | $ | 27,796 |
|  | December 31, 201 6 |
|  | Amortized Cost |  |  | Gross Unrealized Gains |  |  | Gross Unrealized Losses |  |  | Estimated Fair Value |
U.S. corporate debt securities |  | $ | 12,048 |  |  | $ | — |  |  | $ | (9 | ) |  | $ | 12,039 |
Foreign corporate debt |  |  | 14,065 |  |  |  | — |  |  |  | (8 | ) |  |  | 14,057 |
U.S. commercial paper |  |  | 8,635 |  |  |  | — |  |  |  | — |  |  |  | 8,635 |
Foreign commercial paper |  |  | 2,993 |  |  |  | — |  |  |  | — |  |  |  | 2,993 |
Total |  | $ | 37,741 |  |  | $ | — |  |  | $ | (17 | ) |  | $ | 37,724 |
Schedule of Inventory, Current [Table Text Block] |
|  | December 31, |
|  | 2017 |  |  | 2016 |
Raw materials |  | $ | 2,754 |  |  | $ | 1,647 |
Work in process |  |  | 4,166 |  |  |  | 1,104 |
Finished goods |  |  | 3,188 |  |  |  | 2,589 |
Total inventory |  | $ | 10,108 |  |  | $ | 5,340 |
Property, Plant and Equipment [Table Text Block] |
|  | December 31, |
|  | 2017 |  |  | 2016 |
Scientific equipment |  | $ | 9,742 |  |  | $ | 7,952 |
Leasehold improvements |  |  | 1,654 |  |  |  | 1,635 |
Computer equipment and software |  |  | 1,420 |  |  |  | 1,429 |
Furniture, fixtures and office equipment |  |  | 1,024 |  |  |  | 674 |
Property and equipment , gross |  |  | 13,840 |  |  |  | 11,690 |
Less: accumulated depreciation and amortization |  |  | (7,859 | ) |  |  | (6,614 | )
Property and equipment, net |  | $ | 5,981 |  |  | $ | 5,076 |
Schedule of Accrued Liabilities [Table Text Block] |
|  | December 31, |
|  | 20 17 |  |  | 2016 |
Accrued employee salaries and benefits |  | $ | 2,730 |  |  | $ | 2,236 |
Accrued bonuses |  |  | 5,044 |  |  |  | 3,474 |
Accrued expenses for realignment (see Note 6) |  |  | 1,086 |  |  |  | 2,704 |
Total accrued payroll and employee liabilities |  | $ | 8,860 |  |  | $ | 8,414 |
|  | December 31, |
|  | 2017 |  |  | 2016 |
Accrued consulting and professional fees |  | $ | 6,869 |  |  | $ | 4,703 |
Accrued accounts payable |  |  | 148 |  |  |  | 1,039 |
Accrued product sales allowances |  |  | 9,319 |  |  |  | 342 |
Deferred rent |  |  | 651 |  |  |  | 116 |
Other accrued liabilities |  |  | 188 |  |  |  | 88 |
Total other accrued liabilities |  | $ | 17,175 |  |  | $ | 6,288 |

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