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Note 8 - Stockholders' Equity (Details Textual) - USD ($) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Dec. 01, 2007 | Dec. 31, 2017 | Jun. 30, 2017 | Jan. 31, 2017 | Jun. 30, 2016 | Jun. 30, 2015 | May 31, 2015 | May 30, 2015 | May 31, 2014 | May 30, 2014 | Jun. 30, 2011 | May 31, 2010 | May 30, 2009 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Jun. 30, 2014 | Dec. 31, 2007
Proceeds from Issuance or Sale of Equity |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 306,279 |  | $ 128,199 |  |
Proceeds from Issuance of Common Stock |  | $ 142,600 |  | $ 163,700 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  | 620,164 |  |  |  |  |  |  |  |  |  |  |  | 620,164 |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8.49 | $ 8.37 | $ 9.15 |  |
Common Stock, Shares, Issued |  | 64,609 |  |  |  |  |  |  |  |  |  |  |  | 64,609 | 39,355 |  |  |
Common Stock, Capital Shares Reserved for Future Issuance |  | 27,018,833 |  |  |  |  |  |  |  |  |  |  |  | 27,018,833 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant |  | 4,685,432 |  |  |  |  |  |  |  |  |  |  |  | 4,685,432 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  |  |  |  |  |  |  |  |  |  |  |  | 10 years |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  |  |  |  |  |  |  |  |  |  |  |  | 4 years |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period |  |  |  |  |  |  |  |  |  |  |  |  |  | 993,920 |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 17.77 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period |  |  |  |  |  |  |  |  |  |  |  |  |  | 338,509 |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 26.81 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term |  |  |  |  |  |  |  |  |  |  |  |  |  | 6 years 182 days |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 9,900 | $ 10,400 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value |  | $ 35,600 |  |  |  |  |  |  |  |  |  |  |  | 35,600 | 16,900 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value |  | $ 35,600 |  |  |  |  |  |  |  |  |  |  |  | $ 35,600 | $ 16,900 |  |  |
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Outstanding Options |  | 13,462,963 |  |  |  |  |  |  |  |  |  |  |  | 13,462,963 |  |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized |  | $ 88,200 |  |  |  |  |  |  |  |  |  |  |  | $ 88,200 |  |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |
Employee Stock Purchase Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized | 5,000 |  | 200,000 |  | 100,000 |  |  | 100,000 |  | 25,000 | 25,000 |  | 10,000 | 475,000 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award Maximum Employee Earnings with held to Purchase Common Stock Percent |  |  |  |  |  |  |  |  |  |  |  |  |  | 10.00% |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award Discount on Stock Price |  |  |  |  |  |  |  |  |  |  |  |  |  | 85.00% |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award Eligible Participants Percent |  |  |  |  |  |  |  |  |  |  |  |  |  | 48.00% |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period |  |  |  |  |  |  |  |  |  |  |  |  |  | 77,283 | 54,932 | 30,361 |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 12.80 | $ 14.03 | $ 8.46 |  |
Common Stock, Shares, Issued |  | 207,683 |  |  |  |  |  |  |  |  |  |  |  | 207,683 |  |  |  |
Common Stock, Capital Shares Reserved for Future Issuance |  | 267,317 |  |  |  |  |  |  |  |  |  |  |  | 267,317 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10.61 | 11.82 | 21.92 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Per Share Weighted-average Fair Value Price of Shares Purchased |  | $ 4.51 |  |  |  |  |  |  |  |  |  |  |  | $ 4.51 | $ 6.10 | $ 8.23 |  |
Equity Incentive Plan 2007 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized |  |  | 5,000,000 |  | 3,000,000 |  | 4,300,000 |  | 1,750,000 |  | 4,500,000 | 100,000 |  | 18,800,000 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 150,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant |  | 4,685,432 |  |  |  |  |  |  |  |  |  |  |  | 4,685,432 |  |  |  |
Pre-funded Warrants[Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 600,000 |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.01 |
Class of Warrant or Right, Exercised During Period |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,426 |  |  |  |
Class of Warrant or Right, Outstanding |  | 595,574 |  |  |  |  |  |  |  |  |  |  |  | 595,574 |  |  |  |
Private Placement 2011 [Member] | Warrants Issued in Connection with the 2011 Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  |  |  |  |  |  |  |  | 4,000,000 |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  |  |  |  |  |  |  |  |  | $ 3.60 |  |  |  |  |  |  |
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues |  | 9,700,000 |  | 14,100,000 |  | 5,500,000 |  |  |  |  |  |  |  | 23,822,000 |  | 5,520,000 |  |
Sale of Stock, Price Per Share |  |  |  |  |  | $ 24.75 |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity |  |  |  |  |  | $ 128,200 |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs |  | $ 7,400 |  | $ 8,800 |  | $ 8,400 |  |  |  |  |  |  |  |  |  |  |  |
Share Price |  | $ 15.50 |  | $ 12.20 |  |  |  |  |  |  |  |  |  | $ 15.50 |  |  |  |
Stock Issued During Period, Shares, Warrants Exercised |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,000 | 2,396,000 | 286,000 |  |
Common Stock [Member] | Pre-funded Warrants[Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Warrants Exercised |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,423 |  |  |  |
Common Stock [Member] | Private Placement 2011 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,395,700 | 285,713 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Exercised |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,965,477 | 343,813 |  |

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- Definition The purchase price of stock from 1997 Employee Stock Purchase Plan will be the lower of the closing price of common stock on: (i) the first trading day in the enrollment period, as defined in the Purchase Plan, in which the purchase is made, or (ii) the purchase date. + References No definition available. + Details
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- Definition Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (i) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The cash outflow for cost incurred directly with the issuance of an equity security. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3291-108585 + Details
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- Definition Number of non-option equity instruments exercised by participants. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(2) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Number of additional shares authorized for issuance under an established share-based compensation plan. + References No definition available. + Details
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- Definition The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(3) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d)(2) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(4) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(3) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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