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Note 9 - Income Taxes (Details Textual) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Income Tax Expense (Benefit) |  |  | $ 0 | $ 0 | $ 0
Deferred Tax Assets, Tax Credit Carryforwards, Research | $ 25,919 |  | $ 25,919 | 16,687 |
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent |  |  | 35.00% |  |
Adjustment of Deferred Tax (Asset) Liability, Revaluation Based On New Tax Rate | 74,300 |  |  |  |
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued | 0 |  | $ 0 | 0 |
Unrecognized Tax Benefits | 100 |  | 100 | 100 |
Unrecognized Tax Benefits that Would Impact Effective Tax Rate |  |  |  | $ 100 |
Deferred Tax Assets Revaluated [Member] |  |  |  |  |
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount | (74,300) |  |  |  |
Scenario, Forecast [Member] |  |  |  |  |
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent |  | 21.00% |  |  |
Domestic Tax Authority [Member] |  |  |  |  |
Operating Loss Carryforwards | 557,900 |  | 557,900 |  |
Deferred Tax Assets, Tax Credit Carryforwards, Research | 17,600 |  | 17,600 |  |
State and Local Jurisdiction [Member] |  |  |  |  |
Operating Loss Carryforwards | 300,600 |  | 300,600 |  |
Deferred Tax Assets, Tax Credit Carryforwards, Research | $ 10,500 |  | $ 10,500 |  |

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