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Note 6 - Realignment of Goals and Objectives and New Development Focus (Details Textual) $ in Millions | 12 Months Ended | 15 Months Ended
--- | --- | ---
Dec. 31, 2017 USD ($) | Dec. 31, 2017 USD ($)
Restructuring and Related Cost, Expected Cost | $ 9.6 | $ 9.6
Restructuring Plan [Member] |  |
Restructuring Charges | 1.8 | 9.6
Payments for Restructuring | 4.6 |
Restructuring Plan [Member] | Research and Development Expense [Member] |  |
Restructuring Charges | 1.5 |
Restructuring Plan [Member] | General and Administrative Expense [Member] |  |
Restructuring Charges | 0.3 |
Restructuring Plan [Member] | Accrued Payroll and Employee Liabilities [Member] |  |
Restructuring and Related Cost, Cost Incurred to Date | 1.1 | 1.1
Restructuring Plan [Member] | Employee Severance [Member] |  |
Restructuring and Related Cost, Expected Cost | 5.7 | 5.7
Restructuring Plan [Member] | Accelerated Non-Cash Stock Option Expense [Member] |  |
Restructuring and Related Cost, Expected Cost | $ 3.9 | $ 3.9

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