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Note 9 - Income Taxes - Components of Deferred Tax Assets (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforward | $ 134,659 | $ 138,727
Research and development credits | 25,919 | 16,687
Stock-based compensation | 8,633 | 10,272
Other | 2,920 | 3,204
Total gross deferred tax assets | 172,131 | 168,890
Valuation allowance | (172,131) | (168,890)
Net deferred tax assets |  |

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