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Note 4 - Balance Sheet Details (Tables)

12 Months Ended

Dec. 31, 2017

Available-for-sale Securities [Table Text Block]

	December 31, 201 7
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
U.S. corporate debt securities	$	13,003	$	—	$	(10	)	$	12,993
U.S. commercial paper		4,929		—		—			4,929
Foreign commercial paper		9,874		—		—			9,874
Total	$	27,806	$	—	$	(10	)	$	27,796

	December 31, 201 6
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
U.S. corporate debt securities	$	12,048	$	—	$	(9	)	$	12,039
Foreign corporate debt		14,065		—		(8	)		14,057
U.S. commercial paper		8,635		—		—			8,635
Foreign commercial paper		2,993		—		—			2,993
Total	$	37,741	$	—	$	(17	)	$	37,724

Schedule of Inventory, Current [Table Text Block]

	December 31,
	2017		2016
Raw materials	$	2,754	$	1,647
Work in process		4,166		1,104
Finished goods		3,188		2,589
Total inventory	$	10,108	$	5,340

Property, Plant and Equipment [Table Text Block]

	December 31,
	2017			2016
Scientific equipment	$	9,742		$	7,952
Leasehold improvements		1,654			1,635
Computer equipment and software		1,420			1,429
Furniture, fixtures and office equipment		1,024			674
Property and equipment , gross		13,840			11,690
Less: accumulated depreciation and amortization		(7,859	)		(6,614	)
Property and equipment, net	$	5,981		$	5,076

Schedule of Accrued Liabilities [Table Text Block]

	December 31,
	20 17		2016
Accrued employee salaries and benefits	$	2,730	$	2,236
Accrued bonuses		5,044		3,474
Accrued expenses for realignment (see Note 6)		1,086		2,704
Total accrued payroll and employee liabilities	$	8,860	$	8,414

	December 31,
	2017		2016
Accrued consulting and professional fees	$	6,869	$	4,703
Accrued accounts payable		148		1,039
Accrued product sales allowances		9,319		342
Deferred rent		651		116
Other accrued liabilities		188		88
Total other accrued liabilities	$	17,175	$	6,288

- Definition

Tabular disclosure of available-for-sale securities which includes, but is not limited to, changes in the cost basis and fair value, fair value and gross unrealized gain (loss), fair values by type of security, contractual maturity and classification, amortized cost basis, contracts to acquire securities to be accounted for as available-for-sale, debt maturities, transfers to trading, change in net unrealized holding gain (loss) net of tax, continuous unrealized loss position fair value, aggregate losses qualitative disclosures, other than temporary impairment (OTTI) losses or other disclosures related to available for sale securities.

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