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Note 8 - Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2017

Notes Tables

Common Stock Reserved for Future Issuance [Table Text Block]

		Number of Shares
Stock options outstanding			13,462,963
Stock options available for grant			4,685,432
Employee stock purchase plan			267,317
Warrants outstanding			620,164
Shares of c ommon stock underlying Convertible Notes outstanding (see Note 7)			7,982,957
Total shares reserved for future issuance			27,018,833

Share-based Compensation, Stock Options, Activity [Table Text Block]

		Outstanding Options
		Number of Shares				Weighted- Average Exercise Price
Balance at December 31, 2014			7,918,004			$	8.69
Granted			2,134,505				28.95
Exercised			(1,042,343	)			9.15
Cancelled			(575,178	)			10.42
Balance at Decemb er 31, 2015			8,434,988				13.64
Granted			4,920,661				15.98
Exercised			(798,363	)			8.37
Cancelled			(711,910	)			22.43
Balance at Decemb er 31, 2016			11,845,376				14.44
Granted			4,300,621				16.17
Exercised			(1,350,605	)			8.49
Cancelled			(1,332,429	)			20.06
Balance at December 31, 2017			13,462,963				15.03

Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding and Exercisable [Table Text Block]

		Years Ended December 31,
		2017								2016								2015
		Options				Weighted- Average Exercise Price				Options				Weighted- Average Exercise Price				Options				Weighted- Average Exercise Price
Exercisable at end of year			5,446,586			$	13.25				4,356,665			$	11.66				2,587,392			$	8.72
Options vested or expected to vest			12,854,571			$	14.98				11,234,529			$	14.32				8,059,481			$	13.38

Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]

																				Weighted-
								Weighted-												Average
								Average				Weighted-								Exercise
								Remaining				Average								Price of
Options			Range of					Contractual				Exercise				Options				Options
Outstanding			Exercise Prices					Life (in years)				Price				Exercisable				Exercisable
34,906				$5.20					3.04			$	5.20				34,906			$	5.20
1,962,586			$6.60	–	$7.20				5.30				7.19				1,587,586				7.18
1,894,556			$ 8.80	–	$12.90				6.23				9.55				1,610,345				9.54
1,895,717				$13.00					8.88				13.00				532,872				13.00
1,900,182			$13.05	–	$16.30				8.90				14.95				278,933				15.12
1,029,700			$16.35	–	$16.90				8.65				16.81				342,983				16.82
4,745,316			$17.00	–	$38.46				9.02				21.00				1,058,961				26.73
13,462,963			$ 5.20	–	$38.46				8.01				15.03				5,446,586				13.25

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		December 31,
		2017				2016				2015
Research and development		$	11,312			$	11,316			$	4,701
General and administrative			9,469				7,402				6,282
Sales and marketing			9,757				7,238				3,377
Total s tock-based compensation expense		$	30,538			$	25,956			$	14,360

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		December 31,
		2017				2016				2015
Risk-free interest rate			2.1	%			1.7	%			1.7	%
Dividend yield			—	%			—	%			—	%
Volatility			74.0	%			89.1	%			92.7	%
Expected life (years)			6				6				6

		December 31,
		2017				2016				2015
Risk-free interest rate			1.2	%			0.4	%			0.1	%
Dividend yield			—	%			—	%			—	%
Volatility			50.0	%			68.3	%			86.7	%
Expecte d life (months)			6				6				6

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