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Note 9 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Notes Tables

Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]

		December 31,
		2017				2016				2015
Tax at statutory federal rate		$	( 67,145	)		$	( 58,868	)		$	( 33,181	)
State tax, net of federal benefit			( 6,203	)			2,013				( 5,753	)
Research and development credits			( 5,962	)			( 4,206	)			( 2,757	)
Stock-based compensation expense			3,151				2,694				894
Non-deductible compensation			—				1,864				—
Change in valuation allowance			3,241				55,173				40,445
Impact of the 2017 Tax Act			74,361				—				—
Other			( 1,443	)			1,330				352
Provision for income taxes		$	—			$	—			$	—

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

		December 31,
		2017				2016
Deferred tax assets:
Net operating loss carryforward		$	134,659			$	138,727
Research and development credits			25,919				16,687
Stock-based compensation			8,633				10,272
Other			2,920				3,204
Total gross deferred tax assets			172,131				168,890
Valuation allowance			(172,131	)			(168,890	)
Net deferred tax assets		$	—			$	—

X

- Definition

Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319

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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

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