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Note 2 - Summary of Significant Accounting Policies (Details Textual)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Property, Plant and Equipment, Useful Life   5 years  
Deferred Revenue, Current   $ 2,763 $ 1,099
Deferred Tax Assets, Gross   172,131 168,890
Deferred Tax Assets, Valuation Allowance   172,131 $ 168,890
Accounting Standards Update 2016-09 [Member]      
Deferred Tax Assets, Gross   3,600  
Deferred Tax Assets, Valuation Allowance   $ 3,600  
Accounting Standards Update 2014-09 [Member] | Scenario, Forecast [Member]      
Cumulative Effect on Retained Earnings, before Tax $ 1,900    
Sales Revenue, Goods, Gross 2,900    
Sales Allowances, Goods $ 1,000    
Customer Concentration Risk [Member] | Sales Revenue, Net [Member] | SUSTOL [Member]      
Number of Major Customers   2