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Note 6 - Realignment of Goals and Objectives and New Development Focus (Details Textual) $ in Millions	12 Months Ended	15 Months Ended
	Dec. 31, 2017 USD ($)	Dec. 31, 2017 USD ($)
Restructuring and Related Cost, Expected Cost	$ 9.6	$ 9.6
Restructuring Plan [Member]
Restructuring Charges	1.8	9.6
Payments for Restructuring	4.6
Restructuring Plan [Member] | Research and Development Expense [Member]
Restructuring Charges	1.5
Restructuring Plan [Member] | General and Administrative Expense [Member]
Restructuring Charges	0.3
Restructuring Plan [Member] | Accrued Payroll and Employee Liabilities [Member]
Restructuring and Related Cost, Cost Incurred to Date	1.1	1.1
Restructuring Plan [Member] | Employee Severance [Member]
Restructuring and Related Cost, Expected Cost	5.7	5.7
Restructuring Plan [Member] | Accelerated Non-Cash Stock Option Expense [Member]
Restructuring and Related Cost, Expected Cost	$ 3.9	$ 3.9

X

- Definition

Amount of cash payments made as the result of exit or disposal activities. Excludes payments associated with a discontinued operation or an asset retirement obligation.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)(2)
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-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 25
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Amount of costs incurred to date for the specified restructuring cost.

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-Publisher FASB
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-SubTopic 10
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-Subparagraph (SAB Topic 5.P.4(b))
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Amount expected to be recognized in earnings for the specified restructuring cost.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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-SubTopic 10
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-Subparagraph (b)
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+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 5.P.3)
-URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140864-122747

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