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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenues:      
Net product sales $ 30,767 $ 1,279
Operating expenses:      
Cost of product sales 4,588 35
Research and development 138,582 103,125 61,183
General and administrative 25,554 21,366 18,395
Sales and marketing 56,601 47,668 17,347
Total operating expenses 225,325 172,194 96,925
Loss from operations (194,558) (170,915) (96,925)
Other expense, net:      
Interest income 1,049 445 174
Interest expense (3,937) (2,664) (958)
Other (expense) income (38) (9) 118
Total other expense, net (2,926) (2,228) (666)
Net loss (197,484) (173,143) (97,591)
Other comprehensive loss:      
Net unrealized loss on short-term investments 7 23 (40)
Comprehensive loss $ (197,477) $ (173,120) $ (97,631)
Basic and diluted net loss per share (in dollars per share) $ (3.65) $ (4.56) $ (2.95)
Shares used in computing basic and diluted net loss per share (in shares) 54,040 37,925 33,081