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Note 8 - Stockholders' Equity - Exercise Price Range (Details)
 12 Months Ended
Dec. 31, 2017
$ / shares
shares
Options Outstanding (in shares) | shares 13,462,963
Range of Exercise Prices, Lower Limit (in dollars per share) $ 5.20
Range of Exercise Prices, Upper Limit (in dollars per share) $ 38.46
Weighted- Average Remaining Contractual Life (Year) 8 years 3 days
Weighted- Average Exercise Price (in dollars per share) $ 15.03
Options Exercisable (in shares) | shares 5,446,586
Weighted- Average Exercise Price of Options Exercisable (in dollars per share) $ 13.25
Exercise Price Range 1 [Member]  
Options Outstanding (in shares) | shares 34,906
Range of Exercise Prices, Lower Limit (in dollars per share) $ 5.20
Range of Exercise Prices, Upper Limit (in dollars per share) $ 5.20
Weighted- Average Remaining Contractual Life (Year) 3 years 14 days
Weighted- Average Exercise Price (in dollars per share) $ 5.20
Options Exercisable (in shares) | shares 34,906
Weighted- Average Exercise Price of Options Exercisable (in dollars per share) $ 5.20
Exercise Price Range 2 [Member]  
Options Outstanding (in shares) | shares 1,962,586
Range of Exercise Prices, Lower Limit (in dollars per share) $ 6.60
Range of Exercise Prices, Upper Limit (in dollars per share) $ 7.20
Weighted- Average Remaining Contractual Life (Year) 5 years 109 days
Weighted- Average Exercise Price (in dollars per share) $ 7.19
Options Exercisable (in shares) | shares 1,587,586
Weighted- Average Exercise Price of Options Exercisable (in dollars per share) $ 7.18
Exercise Price Range 3 [Member]  
Options Outstanding (in shares) | shares 1,894,556
Range of Exercise Prices, Lower Limit (in dollars per share) $ 8.80
Range of Exercise Prices, Upper Limit (in dollars per share) $ 12.90
Weighted- Average Remaining Contractual Life (Year) 6 years 83 days
Weighted- Average Exercise Price (in dollars per share) $ 9.55
Options Exercisable (in shares) | shares 1,610,345
Weighted- Average Exercise Price of Options Exercisable (in dollars per share) $ 9.54
Exercise Price Range 4 [Member]  
Options Outstanding (in shares) | shares 1,895,717
Range of Exercise Prices, Lower Limit (in dollars per share) $ 13
Range of Exercise Prices, Upper Limit (in dollars per share) $ 13
Weighted- Average Remaining Contractual Life (Year) 8 years 321 days
Weighted- Average Exercise Price (in dollars per share) $ 13
Options Exercisable (in shares) | shares 532,872
Weighted- Average Exercise Price of Options Exercisable (in dollars per share) $ 13
Exercise Price Range 5 [Member]  
Options Outstanding (in shares) | shares 1,900,182
Range of Exercise Prices, Lower Limit (in dollars per share) $ 13.05
Range of Exercise Prices, Upper Limit (in dollars per share) $ 16.30
Weighted- Average Remaining Contractual Life (Year) 8 years 328 days
Weighted- Average Exercise Price (in dollars per share) $ 14.95
Options Exercisable (in shares) | shares 278,933
Weighted- Average Exercise Price of Options Exercisable (in dollars per share) $ 15.12
Exercise Price Range 6 [Member]  
Options Outstanding (in shares) | shares 1,029,700
Range of Exercise Prices, Lower Limit (in dollars per share) $ 16.35
Range of Exercise Prices, Upper Limit (in dollars per share) $ 16.90
Weighted- Average Remaining Contractual Life (Year) 8 years 237 days
Weighted- Average Exercise Price (in dollars per share) $ 16.81
Options Exercisable (in shares) | shares 342,983
Weighted- Average Exercise Price of Options Exercisable (in dollars per share) $ 16.82
Exercise Price Range 7 [Member]  
Options Outstanding (in shares) | shares 4,745,316
Range of Exercise Prices, Lower Limit (in dollars per share) $ 17
Range of Exercise Prices, Upper Limit (in dollars per share) $ 38.46
Weighted- Average Remaining Contractual Life (Year) 9 years 7 days
Weighted- Average Exercise Price (in dollars per share) $ 21
Options Exercisable (in shares) | shares 1,058,961
Weighted- Average Exercise Price of Options Exercisable (in dollars per share) $ 26.73