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Note 9 - Income Taxes (Details Textual) - USD ($)
$ in Thousands
 1 Months Ended 12 Months Ended
Dec. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Income Tax Expense (Benefit)     $ 0 $ 0 $ 0
Deferred Tax Assets, Tax Credit Carryforwards, Research $ 25,919   $ 25,919 16,687  
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent     35.00%    
Adjustment of Deferred Tax (Asset) Liability, Revaluation Based On New Tax Rate 74,300        
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued 0   $ 0 0  
Unrecognized Tax Benefits 100   100 100  
Unrecognized Tax Benefits that Would Impact Effective Tax Rate       $ 100  
Deferred Tax Assets Revaluated [Member]          
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount (74,300)        
Scenario, Forecast [Member]          
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent   21.00%      
Domestic Tax Authority [Member]          
Operating Loss Carryforwards 557,900   557,900    
Deferred Tax Assets, Tax Credit Carryforwards, Research 17,600   17,600    
State and Local Jurisdiction [Member]          
Operating Loss Carryforwards 300,600   300,600    
Deferred Tax Assets, Tax Credit Carryforwards, Research $ 10,500   $ 10,500