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Note 9 - Income Taxes - Provisions (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Tax at statutory federal rate	$ (67,145)	$ (58,868)	$ (33,181)
State tax, net of federal benefit	(6,203)	2,013	(5,753)
Research and development credits	(5,962)	(4,206)	(2,757)
Stock-based compensation expense	3,151	2,694	894
Non-deductible compensation		1,864
Change in valuation allowance	3,241	55,173	40,445
Impact of the 2017 Tax Act	74,361
Other	(1,443)	1,330	352
Provision for income taxes	$ 0	$ 0	$ 0

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to compensation nondeductible expenses.

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