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Consolidated Statements of Stockholders' Equity (Deficit) - USD ($)
$ in Thousands
Common Stock [Member]
Additional Paid-in Capital [Member]
AOCI Attributable to Parent [Member]
Retained Earnings [Member]
Total
Balance (in shares) at Dec. 31, 2014 29,227,000        
Balance at Dec. 31, 2014 $ 292 $ 378,007 $ (315,237) $ 63,062
Issuance of common stock in a public offering, net (in shares) 5,520,000        
Issuance of common stock in a public offering, net $ 55 128,144 128,199
Conversion benefit included in Convertible Notes issued 328 328
Issuance of common stock under Employee Stock Purchase Plan (in shares) 31,000        
Issuance of common stock under Employee Stock Purchase Plan 257 $ 257
Issuance of common stock on exercise of stock options (in shares) 1,042,000       1,042,343
Issuance of common stock on exercise of stock options $ 11 9,524 $ 9,535
Issuance of common stock on exercise of warrants (in shares) 286,000        
Issuance of common stock on exercise of warrants $ 3 (3)
Stock-based compensation expense 14,360 14,360
Net loss (97,591) (97,591)
Net unrealized loss on short-term investments (40) (40)
Comprehensive loss (97,631)
Balance (in shares) at Dec. 31, 2015 36,106,000        
Balance at Dec. 31, 2015 $ 361 530,617 (40) (412,828) 118,110
Conversion benefit included in Convertible Notes issued 348 348
Issuance of common stock under Employee Stock Purchase Plan (in shares) 55,000        
Issuance of common stock under Employee Stock Purchase Plan $ 1 770 $ 771
Issuance of common stock on exercise of stock options (in shares) 798,000       798,363
Issuance of common stock on exercise of stock options $ 8 6,676 $ 6,684
Issuance of common stock on exercise of warrants (in shares) 2,396,000        
Issuance of common stock on exercise of warrants $ 24 (24)
Stock-based compensation expense 25,956 25,956
Net loss (173,143) (173,143)
Net unrealized loss on short-term investments 23 23
Comprehensive loss (173,120)
Balance (in shares) at Dec. 31, 2016 39,355,000        
Balance at Dec. 31, 2016 $ 394 564,343 (17) (585,971) (21,251)
Issuance of common stock in a public offering, net (in shares) 23,822,000        
Issuance of common stock in a public offering, net $ 238 306,041 306,279
Conversion benefit included in Convertible Notes issued 369 369
Issuance of common stock under Employee Stock Purchase Plan (in shares) 77,000        
Issuance of common stock under Employee Stock Purchase Plan $ 1 988 $ 989
Issuance of common stock on exercise of stock options (in shares) 1,351,000       1,350,605
Issuance of common stock on exercise of stock options $ 13 11,450 $ 11,463
Issuance of common stock on exercise of warrants (in shares) 4,000        
Issuance of common stock on exercise of warrants
Stock-based compensation expense 30,538 30,538
Net loss (197,484) (197,484)
Net unrealized loss on short-term investments 7 7
Comprehensive loss (197,477)
Issuance of warrants 226 226
Balance (in shares) at Dec. 31, 2017 64,609,000        
Balance at Dec. 31, 2017 $ 646 $ 913,955 $ (10) $ (783,455) $ 131,136