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Note 11 - Summary of Quarterly Consolidated Financial Data (Unaudited) - Summary Quarterly Results of Operations (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenues:                      
Net product sales $ 10,053 $ 8,572 $ 8,510 $ 3,632 $ 1,279 $ 30,767 $ 1,279
Cost of product sales (1,338) (1,051) (1,013) (1,186) (35) (4,588) (35)
Gross Profit 8,715 7,521 7,497 2,446 1,244      
Operating expenses:                      
Research and development 47,757 28,844 28,597 33,384 29,505 30,242 27,286 16,092 138,582 103,125 61,183
General and administrative 6,165 6,462 6,185 6,742 5,892 5,333 4,774 5,367 25,554 21,366 18,395
Sales and marketing 16,683 13,529 14,770 11,619 12,650 12,159 11,006 11,853 56,601 47,668 17,347
Loss from operations (61,890) (41,314) (42,055) (49,299) (46,803) (47,734) (43,066) (33,312)      
Other expense, net (600) (552) (744) (1,030) (1,160) (775) (160) (133) (38) (9) 118
Net loss $ (62,490) $ (41,866) $ (42,799) $ (50,329) $ (47,963) $ (48,509) $ (43,226) $ (33,445) $ (197,484) $ (173,143) $ (97,591)
Basic and diluted net loss per share (in dollars per share) $ (1.09) $ (0.77) $ (0.80) $ (1) $ (1.22) $ (1.24) $ (1.17) $ (0.92) $ (3.65) $ (4.56) $ (2.95)