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Note 3 - Accounting Policies (Tables)
3 Months Ended
Mar. 31, 2018
Notes Tables  
Available-for-sale Securities [Table Text Block]
   
March 31, 2018
 
   
 
 
 
 
Gross
   
Gross
   
 
 
 
   
Amortized
   
Unrealized
   
Unrealized
   
Estimated
 
   
Cost
   
Gains
   
Losses
   
Fair Value
 
U.S. corporate debt securities
  $
16,202
    $
    $
(42
)
  $
16,160
 
U.S. commercial paper
   
17,402
     
     
     
17,402
 
Foreign commercial paper
   
33,801
     
     
     
33,801
 
Total
  $
67,405
    $
    $
(42
)
  $
67,363
 
   
D
ecember 31, 2017
 
   
 
 
 
 
Gross
   
Gross
   
 
 
 
   
Amortized
   
Unrealized
   
Unrealized
   
Estimated
 
   
Cost
   
Gains
   
Losses
   
Fair Value
 
U.S. corporate debt securities
  $
13,003
    $
    $
(10
)
  $
12,993
 
U.S. commercial paper
   
4,929
     
     
     
4,929
 
Foreign commercial paper
   
9,874
     
     
     
9,874
 
Total
  $
27,806
    $
    $
(10
)
  $
27,796
 
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
As of March
3
1
,
 
   
2018
   
2017
 
                 
Stock options outstanding
   
12,906
     
11,849
 
Warrants outstanding
   
640
     
625
 
Shares of common stock underlying Convertible Notes outstanding
   
8,103
     
7,634