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Note 5 - Revenue Recognition (Tables)
 3 Months Ended
Mar. 31, 2018
Notes Tables  
Schedule of Assets and Liabilities as Adjusted due to Adoption of Topic 606 [Table Text Block]
   
As
Reported
U
nder Topic 605
    
Effect of
Change
    
As
Adjusted
U
nder Topic 606
  
                         
Inventory
   $
10,108
     $
(198
 )   $
9,910
  
Other accrued liabilities
    
17,175
      
992
      
18,167
  
Deferred revenue
    
2,763
      
(2,763
 )    
—
  
Retained earnings
    
(783,455
 )    
1,573
      
(781,882
 )
Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block]
   
As
R
eported
U
nder Topic
606
    
Effect of
Change
    
As Revised
Under Topic
605
  
                         
Consolidated Balance Sheet:
                        
Inventory
   $
19,418
     $
610
     $
20,028
  
Other accrued liabilities
    
20,643
      
(538
 )    
20,105
  
Deferred revenue
    
—
      
2,345
      
2,345
  
Retained earnings
    
(834,147
 )    
(1,197
 )    
(835,344
 )
                         
Consolidated Statement of Operations
and Comprehensive Loss
:		                        
Net product sales
   $
11,567
     $
(36
 )   $
11,531
  
Cost of product sales
    
3,133
      
(412
 )    
2,721
  
Loss from operations
    
(51,990
 )    
376
      
(51,614
 )
Net loss
    
(52,265
 )    
376
      
(51,889
 )
Basic and diluted net loss per share
    
(0.81
 )    
0.01
      
(0.80
 )
                         
Consolidated Statement of
Cash Flows
:		                        
Net loss
   $
(52,265
 )   $
376
     $
(51,889
 )
Adjustments to reconcile net loss to net cash used in operating activities:                        
Inventory
    
(9,508
 )    
(412
 )    
(9,920
 )
Other accrued liabilities
    
2,572
      
454
      
3,026
  
Deferred revenue
    
—
      
(418
 )    
(418
 )
Valuation Allowances and Reserves [Table Text Block]
   
Product
Returns
    
Distributor
Fees
    
Discounts,
Rebates and Administrative Fees
    
Total
  
                                 
Balance at December 31, 2017
   $
521
     $
580
     $
8,218
     $
9,319
  
Provision
    
142
      
1,160
      
11,446
      
12,748
  
Payments/credits
    
—
      
(706
 )    
(8,757
 )    
(9,463
 )
Balance at March 31, 2018
   $
663
     $
1,034
     $
10,907
     $
12,604