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Note 1 - Business (Details Textual) - USD ($)
$ in Thousands
1 Months Ended
Apr. 30, 2018
Dec. 31, 2017
Jan. 31, 2017
Mar. 31, 2018
Jan. 01, 2018
Retained Earnings (Accumulated Deficit), Ending Balance   $ (783,455)   $ (834,147)  
Cash, Cash Equivalents, and Short-term Investments, Total       $ 113,900  
Proceeds from Issuance of Common Stock   $ 142,600 $ 163,700    
Pro Forma [Member]          
Retained Earnings (Accumulated Deficit), Ending Balance         $ (781,882)
Subsequent Event [Member]          
Proceeds from Issuance of Common Stock $ 168,700        
Subsequent Event [Member] | Pro Forma [Member]          
Cash, Cash Equivalents, and Short-term Investments, Total $ 282,600