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Note 5 - Revenue Recognition - Condensed Consolidated Financial Statement as if Revenue from Contracts with Customers Had Been Accounted For (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended
Jan. 01, 2018
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Inventory   $ 19,418   $ 10,108
Other accrued liabilities   20,643   17,175
Deferred revenue     2,763
Retained earnings   (834,147)   $ (783,455)
Net product sales   11,567 $ 3,632  
Cost of product sales   3,133 1,186  
Loss from operations   (51,990) (49,299)  
Net loss   $ (52,265) $ (50,329)  
Basic and diluted net loss per share (in dollars per share)   $ (0.81) $ (1)  
Inventory   $ (9,508) $ 699  
Other accrued liabilities   2,572 1,091  
Deferred revenue   $ 4,136  
Accounting Standards Update 2014-09 [Member]        
Net product sales $ 2,900      
Cost of product sales $ 200      
Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Accounting Standards Update 2014-09 [Member]        
Inventory   610    
Other accrued liabilities   (538)    
Deferred revenue   2,345    
Retained earnings   (1,197)    
Net product sales   (36)    
Cost of product sales   (412)    
Loss from operations   376    
Net loss   $ 376    
Basic and diluted net loss per share (in dollars per share)   $ 0.01    
Inventory   $ (412)    
Other accrued liabilities   454    
Deferred revenue   (418)    
Calculated under Revenue Guidance in Effect before Topic 606 [Member]        
Inventory   20,028    
Other accrued liabilities   20,105    
Deferred revenue   2,345    
Retained earnings   (835,344)    
Net product sales   11,531    
Cost of product sales   2,721    
Loss from operations   (51,614)    
Net loss   $ (51,889)    
Basic and diluted net loss per share (in dollars per share)   $ (0.80)    
Inventory   $ (9,920)    
Other accrued liabilities   3,026    
Deferred revenue   $ (418)