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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenues:
Net product sales	$ 11,567	$ 3,632
Operating expenses:
Cost of product sales	3,133	1,186
Research and development	39,561	33,384
General and administrative	7,028	6,742
Sales and marketing	13,835	11,619
Total operating expenses	63,557	52,931
Loss from operations	(51,990)	(49,299)
Other expense, net	(275)	(1,030)
Net loss	(52,265)	(50,329)
Other comprehensive loss:
Unrealized loss on short-term investments	(32)	(13)
Comprehensive loss	$ (52,297)	$ (50,342)
Basic and diluted net loss per share (in dollars per share)	$ (0.81)	$ (1)
Shares used in computing basic and diluted net loss per share (in shares)	64,724	50,530

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