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Note 10 - Subsequent Events (Details Textual) - USD ($) $ / shares in Units, $ in Millions		1 Months Ended
	May 08, 2018	Apr. 30, 2018	Dec. 31, 2017	Jan. 31, 2017
Proceeds from Issuance of Common Stock			$ 142.6	$ 163.7
Common Stock [Member]
Stock Issued During Period, Shares, New Issues			9,700,000	14,100,000
Share Price			$ 15.50	$ 12.20
Payments of Stock Issuance Costs			$ 7.4	$ 8.8
Subsequent Event [Member]
Proceeds from Issuance of Common Stock		$ 168.7
Subsequent Event [Member] | Lease Amendment to Lease for Additional Office Space in Campus Point Court, San Diego, California [Member]
Lessee, Operating Lease, Term of Contract	7 years 90 days
Lessee, Operating Lease, Liability, Annual Payments, Due Next Twelve Months	$ 0.9
Lessee, Operating Lease, Liability, Annual Payments Due in Final Three Months of Agreement	1.4
Payments for Security Deposit	$ 0.1
Subsequent Event [Member] | Common Stock [Member]
Stock Issued During Period, Shares, New Issues		6,900,000
Share Price		$ 26
Payments of Stock Issuance Costs		$ 9.3

X

- Definition

The amount of annual rent payments due within final three months of agreement.

+ References

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- Definition

The amount of annual payments due in the first twelve months of the lease.

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Term of lessee's operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

+ References

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-SubTopic 20
-Section 50
-Paragraph 3
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