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Note 3 - Accounting Policies (Tables)
6 Months Ended
Jun. 30, 2018
Notes Tables  
Schedules of Concentration of Risk, by Risk Factor [Table Text Block]
   
Net Product Sales
   
Accounts
Receivable
 
   
Three Months Ended
June 30, 2018
   
Six Months Ended
June 30, 2018
   
As of
June 30, 2018
 
                         
Customer A
   
47.0
%    
55.8
%    
58.4
%
Customer B
   
31.3
%    
21.3
%    
22.7
%
Customer C
   
21.2
%    
22.6
%    
18.7
%
Total
   
99.5
%    
99.7
%    
99.8
%
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
 
As of
June 30
,
 
   
2018
   
2017
 
                 
Stock options outstanding
   
12,514
     
11,966
 
Warrants outstanding
   
640
     
625
 
Shares of common stock underlying Convertible Notes outstanding
   
8,224
     
7,749