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Note 7 - Revenue Recognition (Tables)
 6 Months Ended
Jun. 30, 2018
Notes Tables  
Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block]
   
As
Reported
U
nder Topic 605
    
Effect of
Change
    
As
Adjusted
U
nder Topic 606
  
                         
Inventory
   $
10,108
     $
(198
 )   $
9,910
  
Other accrued liabilities
    
17,175
      
991
      
18,166
  
Deferred revenue
    
2,763
      
(2,763
 )    
—
  
Retained earnings
    
(783,455
 )    
1,574
      
(781,881
 )
   
As
R
eported
U
nder Topic
606
    
Effect of
Change
    
As Revised
Under Topic
605
  
                         
Consolidated Balance Sheet as of June 30, 2018:
      
 
      
 
  
Inventory
   $
27,197
     $
1,626
     $
28,823
  
Other accrued liabilities
    
19,702
      
(3,369
 )    
16,333
  
Deferred revenue
    
—
      
9,442
      
9,442
  
Retained earnings
    
(872,816
 )    
(4,447
 )    
(877,263
 )
                         
Consolidated Statement of Operations for the Three Months Ended June 30, 2018
:
  
Net product sales
   $
17,277
     $
(4,266
 )   $
13,011
  
Cost of product sales
    
5,231
      
(1,016
 )    
4,215
  
Loss from operations
    
(38,853
 )    
(3,250
 )    
(42,103
 )
Net loss
    
(38,670
 )    
(3,250
 )    
(41,920
 )
Basic and diluted net loss per share
    
(0.54
 )    
(0.04
 )    
(0.58
 )
                         
Consolidated Statement of Operations for the
Six
Months Ended June 30, 2018
:
  
Net product sales
   $
28,844
     $
(4,301
 )   $
24,543
  
Cost of product sales
    
8,364
      
(1,428
 )    
6,936
  
Loss from operations
    
(90,843
 )    
(2,873
 )    
(93,716
 )
Net loss
    
(90,935
 )    
(2,873
 )    
(93,808
 )
Basic and diluted net loss per share
    
(1.33
 )    
(0.04
 )    
(1.37
 )
                         
Consolidated Statement of Cash Flows
for the Six Months Ended June 30, 2018
:
  
Net loss
   $
(90,935
 )   $
(2,873
 )   $
(93,808
 )
Adjustments to reconcile net loss to net cash used in operating activities:
      
 
  
Inventory
    
(17,287
 )    
(1,428
 )    
(18,715
 )
Other accrued liabilities
    
1,729
      
(2,378
 )    
(649
 )
Deferred revenue
    
—
      
6,679
      
6,679
  
Valuation Allowances and Reserves [Table Text Block]
   
Product
Returns
    
Distributor
Fees
    
Discounts,
Rebates and Administrative Fees
    
Total
  
                                 
Balance at December 31, 2017
   $
521
     $
580
     $
8,218
     $
9,319
  
Provision
    
461
      
2,483
      
20,201
      
23,145
  
Payments/credits
    
—
      
(1,774
 )    
(18,050
 )    
(19,824
 )
Balance at June 30, 2018
   $
982
     $
1,289
     $
10,369
     $
12,640