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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Net product sales	$ 17,277	$ 8,510	$ 28,844	$ 12,142
Operating expenses:
Cost of product sales	5,231	1,013	8,364	2,199
Research and development	30,159	28,597	69,720	61,981
General and administrative	6,209	6,185	13,237	12,927
Sales and marketing	14,531	14,770	28,366	26,389
Total operating expenses	56,130	50,565	119,687	103,496
Loss from operations	(38,853)	(42,055)	(90,843)	(91,354)
Other income (expense), net	183	(744)	(92)	(1,774)
Net loss	(38,670)	(42,799)	(90,935)	(93,128)
Other comprehensive income (loss):
Unrealized gains (losses) on short-term investments	17	24	(15)	11
Comprehensive loss	$ (38,653)	$ (42,775)	$ (90,950)	$ (93,117)
Basic and diluted net loss per share (in dollars per share)	$ (0.54)	$ (0.80)	$ (1.33)	$ (1.79)
Shares used in computing basic and diluted net loss per share (in shares)	71,952	53,791	68,358	52,170

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