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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Operating activities:    
Net loss $ (90,935) $ (93,128)
Adjustments to reconcile net loss to net cash used for operating activities:    
Stock-based compensation expense 15,522 16,171
Depreciation and amortization 711 741
Amortization of debt discount 428 374
Loss on disposal of property and equipment 3 5
Accretion of discount on short-term investments (864) (168)
Change in operating assets and liabilities:    
Accounts receivable (4,012) (16,656)
Prepaid expenses and other current assets (3,039) 32
Inventory (17,287) 539
Accounts payable (13,790) (499)
Accrued clinical liabilities (8,934) 1,209
Accrued payroll and employee liabilities (1,974) (1,156)
Deferred revenue 3,689
Other accrued liabilities 1,729 6,236
Net cash used for operating activities (122,442) (82,611)
Investing activities:    
Purchases of short-term investments (157,885) (93,776)
Maturities and sales of short-term investments 22,500 52,693
Purchases of property and equipment (2,238) (1,424)
Net cash used for investing activities (137,623) (42,507)
Financing activities:    
Net proceeds from sale of common stock 363,127 163,747
Repayment of promissory note payable to related party (25,000)
Proceeds from stock option exercises 10,641 2,658
Proceeds from purchases under the Employee Stock Purchase Plan 648 576
Net cash provided by financing activities 374,416 141,981
Net increase in cash and cash equivalents 114,351 16,863
Cash and cash equivalents at beginning of year 144,583 13,414
Cash and cash equivalents at end of period 258,934 30,277
Supplemental disclosure of cash flow information:    
Interest paid 1,000 1,789
Cumulative effect of adoption of new accounting standard $ 1,574