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Note 3 - Accounting Policies (Tables)
9 Months Ended
Sep. 30, 2018
Notes Tables  
Schedules of Concentration of Risk, by Risk Factor [Table Text Block]
   
Net Product Sales
   
Accounts Receivable
 
   
Three Months Ended
September
30, 2018
   
Nine
Months Ended
September
30, 2018
   
As of
September
30, 2018
 
                         
Customer A
   
23.2
%    
42.6
%    
45.4
%
Customer B
   
44.1
%    
30.6
%    
36.1
%
Customer C
   
32.0
%    
26.4
%    
18.3
%
Total
   
99.3
%    
99.6
%    
99.8
%
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
 
As of
September
30
,
 
   
2018
   
2017
 
                 
Stock options outstanding
   
12,300
     
11,198
 
Warrants outstanding
   
640
     
620
 
Shares of common stock underlying Convertible Notes outstanding
   
8,348
     
7,865