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Note 7 - Revenue Recognition (Tables)
 9 Months Ended
Sep. 30, 2018
Notes Tables  
Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block]
   
As
Reported
U
nder Topic 605
    
Effect of
Change
    
As
Adjusted
U
nder Topic 606
  
                         
Inventory
   $
10,108
     $
(198
 )   $
9,910
  
Other accrued liabilities
    
17,175
      
991
      
18,166
  
Deferred revenue
    
2,763
      
(2,763
 )    
—
  
Retained earnings
    
(783,455
 )    
1,574
      
(781,881
 )
   
As
R
eported
U
nder Topic
606
    
Effect of
Change
    
As Revised
Under Topic
605
  
                         
Consolidated Balance Sheet as of September 30, 2018
:
      
 
      
 
  
Inventory
   $
31,412
     $
1,954
     $
33,366
  
Other accrued liabilities
    
27,368
      
(4,628
 )    
22,740
  
Deferred revenue
    
—
      
10,524
      
10,524
  
Retained earnings
    
(911,162
 )    
(3,942
 )    
(915,104
 )
                         
Consolidated Statement of Operations
for the Three Months Ended September
30, 2018
:
  
Net product sales
   $
19,786
     $
177
     $
19,963
  
Cost of product sales
    
7,576
      
(328
 )    
7,248
  
Loss from operations
    
(41,780
 )    
505
      
(41,275
 )
Net loss
    
(38,346
 )    
505
      
(37,841
 )
Basic and diluted net loss per share
    
(0.49
 )    
—
      
(0.49
 )
                         
Consolidated
Statement of Operations for the Nine Months Ended September
30, 2018
:
  
Net product sales
   $
48,630
     $
(4,124
 )   $
44,506
  
Cost of product sales
    
15,940
      
(1,756
 )    
14,184
  
Loss from operations
    
(132,623
 )    
(2,368
 )    
(134,991
 )
Net loss
    
(129,281
 )    
(2,368
 )    
(131,649
 )
Basic and diluted net loss per share
    
(1.81
 )    
(0.03
 )    
(1.84
 )
                         
Consolidated Statement of Cash Flows
for the Nine Months Ended September
30, 2018
:
  
Net loss
   $
(129,281
 )   $
(2,368
 )   $
(131,649
 )
Adjustments to reconcile net loss to net cash used in operating activities:
      
 
  
Inventory
    
(21,502
 )    
(1,756
 )    
(23,258
 )
Other accrued liabilities
    
9,494
      
(3,637
 )    
(5,857
 )
Deferred revenue
    
—
      
7,761
      
7,761
  
Valuation Allowances and Reserves [Table Text Block]
   
Product
Returns
    
Distributor
Fees
    
Discounts,
Rebates and
Administrative
Fees
    
Total
  
                                 
Balance at December 31, 2017
   $
521
     $
580
     $
8,218
     $
9,319
  
Provision
    
178
      
4,342
      
33,764
      
38,284
  
Payments/credits
    
(18
 )    
(3,145
 )    
(25,619
 )    
(28,782
 )
Balance at September 30, 2018
   $
681
     $
1,777
     $
16,363
     $
18,821