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Note 11 - Stockholders' Equity (Tables)

9 Months Ended

Sep. 30, 2018

Notes Tables

Share-based Compensation, Stock Options, Activity [Table Text Block]

										Weighted-
										a verage
						Weighted-				Remaining
						a verage				Contractual
		Shares				Exercise				Term
		(in thousands)				Price				(Years)
Balance at December 31, 2017			13,463			$	15.03				8.01
Granted			725			$	32.42
Exercised			(1,332	)		$	11.84
Expired and forfeited			(556	)		$	17.94
Balance at September 30, 2018			12,300			$	16.27				7.50

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		Three Months Ended September 30,								Nine Months Ended September 30,
		2018				2017				2018				2017
Research and development		$	3,212			$	2,595			$	9,363			$	8,758
General and administrative			2,366				2,419				6,950				7,345
Sales and marketing			2,472				2,462				7,259				7,544
Total stock-based compensation expense		$	8,050			$	7,476			$	23,572			$	23,647

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		September 30 ,
		20 18				20 17
Risk-free interest rate			2.8	%			2.0	%
Dividend yield			0.0	%			0.0	%
Volatility			70.5	%			80.2	%
Expected life (years)			6				6

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