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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Net product sales	$ 19,786	$ 8,572	$ 48,630	$ 20,714
Operating expenses:
Cost of product sales	7,576	1,051	15,940	3,250
Research and development	30,421	28,844	100,141	90,825
General and administrative	7,288	6,462	20,525	19,389
Sales and marketing	16,281	13,529	44,647	39,918
Total operating expenses	61,566	49,886	181,253	153,382
Loss from operations	(41,780)	(41,314)	(132,623)	(132,668)
Other income (expense), net	3,434	(552)	3,342	(2,326)
Net loss	(38,346)	(41,866)	(129,281)	(134,994)
Other comprehensive income (loss):
Unrealized gains (losses) on short-term investments	(17)	6	(32)	17
Comprehensive loss	$ (38,363)	$ (41,860)	$ (129,313)	$ (134,977)
Basic and diluted net loss per share (in dollars per share)	$ (0.49)	$ (0.77)	$ (1.81)	$ (2.55)
Shares used in computing basic and diluted net loss per share (in shares)	77,811	54,176	71,544	52,846

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