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Note 7 - Revenue Recognition - Adoption of Topic 606 (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 9 Months Ended
Jan. 01, 2018
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Inventory $ 9,910 $ 31,412   $ 31,412   $ 10,108
Other accrued liabilities 18,166 27,368   27,368   17,175
Deferred revenue     2,763
Retained earnings (781,881) (911,162)   (911,162)   $ (783,455)
Net product sales   19,786 $ 8,572 48,630 $ 20,714  
Cost of product sales   7,576 1,051 15,940 3,250  
Loss from operations   (41,780) (41,314) (132,623) (132,668)  
Net loss   $ (38,346) $ (41,866) $ (129,281) $ (134,994)  
Basic and diluted net loss per share (in dollars per share)   $ (0.49) $ (0.77) $ (1.81) $ (2.55)  
Inventory       $ (21,502) $ 171  
Other accrued liabilities       9,494 9,585  
Deferred revenue       $ 4,461  
Calculated under Revenue Guidance in Effect before Topic 606 [Member]            
Inventory   $ 33,366   33,366    
Other accrued liabilities   22,740   22,740    
Deferred revenue   10,524   10,524    
Retained earnings   (915,104)   (915,104)    
Net product sales   19,963   44,506    
Cost of product sales   7,248   14,184    
Loss from operations   (41,275)   (134,991)    
Net loss   $ (37,841)   $ (131,649)    
Basic and diluted net loss per share (in dollars per share)   $ (0.49)   $ (1.84)    
Inventory       $ (23,258)    
Other accrued liabilities       (5,857)    
Deferred revenue       7,761    
Accounting Standards Update 2014-09 [Member]            
Inventory (198)          
Other accrued liabilities 991          
Deferred revenue (2,763)          
Retained earnings 1,574          
Net product sales 2,900          
Cost of product sales $ 200          
Accounting Standards Update 2014-09 [Member] | Difference between Revenue Guidance in Effect before and after Topic 606 [Member]            
Inventory   $ 1,954   1,954    
Other accrued liabilities   (4,628)   (4,628)    
Deferred revenue   10,524   10,524    
Retained earnings   (3,942)   (3,942)    
Net product sales   177   (4,124)    
Cost of product sales   (328)   (1,756)    
Loss from operations   505   (2,368)    
Net loss   $ 505   $ (2,368)    
Basic and diluted net loss per share (in dollars per share)     $ (0.03)    
Inventory       $ (1,756)    
Other accrued liabilities       (3,637)    
Deferred revenue       $ 7,761