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Note 5 - Revenue Recognition (Tables) | 12 Months Ended
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Dec. 31, 2018
Notes Tables |
Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block] |
|  | As Reported Under Topic 605 |  |  | Effect of Change |  |  | As Adjusted Under Topic 606 |
Inventory |  | $ | 10,108 |  |  | $ | (198 | ) |  | $ | 9,910 |
Other accrued liabilities |  |  | 17,175 |  |  |  | 991 |  |  |  | 18,166 |
Deferred revenue |  |  | 2,763 |  |  |  | (2,763 | ) |  |  | — |
Accumulated deficit |  |  | (783,455 | ) |  |  | 1,574 |  |  |  | (781,881 | )
|  | As Reported Under Topic 606 |  |  | Effect of Change |  |  | As Calculated Under Topic 605 |
Consolidated Balance Sheet as of December 31, 2018: |  |  |  |  |  |  |  |  |  |  |  |
Inventory |  | $ | 39,032 |  |  | $ | 2,181 |  |  | $ | 41,213 |
Other accrued liabilities |  |  | 32,715 |  |  |  | (7,195 | ) |  |  | 25,520 |
Deferred revenue |  |  | — |  |  |  | 14,010 |  |  |  | 14,010 |
Accumulated deficit |  |  | (960,721 | ) |  |  | (4,634 | ) |  |  | (965,355 | )
Consolidated Statement of Operations for the Year Ended December 31 , 2018 : |  |  |  |  |  |  |  |  |  |  |  |
Net product sales |  | $ | 77,474 |  |  | $ | (5,043 | ) |  | $ | 72,431 |
Cost of product sales |  |  | 27,512 |  |  |  | (1,983 | ) |  |  | 25,529 |
Loss from operations |  |  | (183,937 | ) |  |  | (3,060 | ) |  |  | (186,997 | )
Net loss |  |  | (178,840 | ) |  |  | (3,060 | ) |  |  | (181,900 | )
Basic and diluted net loss per share |  |  | (2.44 | ) |  |  | (0.05 | ) |  |  | (2.49 | )
Consolidated Statement of Cash Flows for the Year Ended December 31 , 2018 : |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  | $ | (178,840 | ) |  | $ | (3,060 | ) |  | $ | (181,900 | )
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |  |  |  |  |  |
Inventory |  |  | (29,122 | ) |  |  | (1,983 | ) |  |  | (31,105 | )
Other accrued liabilities |  |  | 14,941 |  |  |  | (6,204 | ) |  |  | 8,737 |
Deferred revenue |  |  | — |  |  |  | 11,247 |  |  |  | 11,247 |
Valuation Allowances and Reserves [Table Text Block] |
|  | Product Returns |  |  | Distributor Fees |  |  | Discounts, Rebates and Administrative Fees |  |  | Total |
Balance at December 31, 2017 |  | $ | 521 |  |  | $ | 580 |  |  | $ | 8,218 |  |  | $ | 9,319 |
Provision |  |  | 464 |  |  |  | 7,555 |  |  |  | 58,504 |  |  |  | 66,523 |
Payments/credits |  |  | (38 | ) |  |  | (5,322 | ) |  |  | (44,979 | ) |  |  | (50,339 | )
Balance at December 31, 2018 |  | $ | 947 |  |  | $ | 2,813 |  |  | $ | 21,743 |  |  | $ | 25,503 |

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