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Note 3 - Fair Value Measurements - Financial Assets Measured on a Recurring Basis (Details) - Fair Value, Measurements, Recurring [Member] - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Total | $ 323,494 | $ 168,623
Foreign Commercial Paper [Member] |  |
Available-for-sale securities | 123,861 | 19,854
US Treasury Securities [Member] |  |
Available-for-sale securities | 59,741 |
Debt Security, Corporate, US [Member] |  |
Available-for-sale securities | 59,087 | 17,520
United States Commercial Paper [Member] |  |
Available-for-sale securities | 61,885 | 39,863
Debt Security, Corporate, Non-US [Member] |  |
Available-for-sale securities | 5,046 |
Fair Value, Inputs, Level 1 [Member] |  |
Total | 73,615 | 91,386
Fair Value, Inputs, Level 1 [Member] | US Treasury Securities [Member] |  |
Available-for-sale securities | 59,741 |
Fair Value, Inputs, Level 1 [Member] | Debt Security, Corporate, US [Member] |  |
Available-for-sale securities |  |
Fair Value, Inputs, Level 1 [Member] | United States Commercial Paper [Member] |  |
Available-for-sale securities |  |
Fair Value, Inputs, Level 1 [Member] | Debt Security, Corporate, Non-US [Member] |  |
Available-for-sale securities |  |
Fair Value, Inputs, Level 1 [Member] | Foreign Commercial Paper [Member] |  |
Available-for-sale securities |  |
Fair Value, Inputs, Level 2 [Member] |  |
Total | 249,879 | 77,237
Fair Value, Inputs, Level 2 [Member] | US Treasury Securities [Member] |  |
Available-for-sale securities |  |
Fair Value, Inputs, Level 2 [Member] | Debt Security, Corporate, US [Member] |  |
Available-for-sale securities | 59,087 | 17,520
Fair Value, Inputs, Level 2 [Member] | United States Commercial Paper [Member] |  |
Available-for-sale securities | 61,885 | 39,863
Fair Value, Inputs, Level 2 [Member] | Debt Security, Corporate, Non-US [Member] |  |
Available-for-sale securities | 5,046 |
Fair Value, Inputs, Level 2 [Member] | Foreign Commercial Paper [Member] |  |
Available-for-sale securities | 123,861 | 19,854
Fair Value, Inputs, Level 3 [Member] |  |
Total |  |
Fair Value, Inputs, Level 3 [Member] | US Treasury Securities [Member] |  |
Available-for-sale securities |  |
Fair Value, Inputs, Level 3 [Member] | Debt Security, Corporate, US [Member] |  |
Available-for-sale securities |  |
Fair Value, Inputs, Level 3 [Member] | United States Commercial Paper [Member] |  |
Available-for-sale securities |  |
Fair Value, Inputs, Level 3 [Member] | Debt Security, Corporate, Non-US [Member] |  |
Available-for-sale securities |  |
Fair Value, Inputs, Level 3 [Member] | Foreign Commercial Paper [Member] |  |
Available-for-sale securities |  |
Money Market Funds [Member] |  |
Available-for-sale securities | 13,874 | 91,386
Money Market Funds [Member] | Fair Value, Inputs, Level 1 [Member] |  |
Available-for-sale securities | 13,874 | 91,386
Money Market Funds [Member] | Fair Value, Inputs, Level 2 [Member] |  |
Available-for-sale securities |  |
Money Market Funds [Member] | Fair Value, Inputs, Level 3 [Member] |  |
Available-for-sale securities |  |

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