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Note 2 - Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2018
Notes Tables |
Schedules of Concentration of Risk, by Risk Factor [Table Text Block] |
|  | Net Product Sales |  |  | Accounts Receivable |
|  | Year Ended December 31 , 2018 |  |  | As of December 31 , 2018 |
Customer A |  |  | 41.7 | % |  |  | 38.7 | %
Customer B |  |  | 34.9 | % |  |  | 46.1 | %
Customer C |  |  | 22.5 | % |  |  | 14.8 | %
Total |  |  | 99.1 | % |  |  | 99.6 | %
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] |
|  | December 31 , |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Stock options outstanding |  |  | 15,265 |  |  |  | 13,463 |  |  |  | 11,845 |
Warrants outstanding |  |  | 640 |  |  |  | 620 |  |  |  | 600 |
Shares of common stock underlying Convertible Notes outstanding |  |  | 8,473 |  |  |  | 7,983 |  |  |  | 7,521 |

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