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Note 10 - Income Taxes (Details Textual) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Income Tax Expense (Benefit), Total | $ 0 | $ 0 | $ 0 |
Deferred Tax Assets, Tax Credit Carryforwards, Research | $ 35,670 | $ 25,919 |  |
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent | 21.00% | 35.00% |  |
Adjustment of Deferred Tax (Asset) Liability, Revaluation Based On New Tax Rate |  | $ 74,300 |  |
Unrecognized Tax Benefits, Ending Balance | $ 2,385 | 120 | $ 120 | $ 120
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total | 0 | 0 |  |
Deferred Tax Assets Revaluated [Member] |  |  |  |
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount |  | $ (74,300) |  |
Domestic Tax Authority [Member] |  |  |  |
Operating Loss Carryforwards, Total | 715,300 |  |  |
Expiring Operating Loss Carryforwards | 549,700 |  |  |
Indefinite Operating Loss Carryforwards | 165,600 |  |  |
Deferred Tax Assets, Tax Credit Carryforwards, Research | 27,200 |  |  |
State and Local Jurisdiction [Member] |  |  |  |
Deferred Tax Assets, Tax Credit Carryforwards, Research | 13,300 |  |  |
State and Local Jurisdiction [Member] | California Franchise Tax Board [Member] |  |  |  |
Operating Loss Carryforwards, Total | 122,300 |  |  |
State and Local Jurisdiction [Member] | Other State Jurisdiction [Member] |  |  |  |
Operating Loss Carryforwards, Total | $ 824,900 |  |  |

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