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Note 2 - Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2018

Notes Tables

Schedules of Concentration of Risk, by Risk Factor [Table Text Block]

		Net Product Sales				Accounts Receivable
		Year Ended December 31 , 2018				As of December 31 , 2018
Customer A			41.7	%			38.7	%
Customer B			34.9	%			46.1	%
Customer C			22.5	%			14.8	%
Total			99.1	%			99.6	%

Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]

		December 31 ,
		2018				2017				2016
Stock options outstanding			15,265				13,463				11,845
Warrants outstanding			640				620				600
Shares of common stock underlying Convertible Notes outstanding			8,473				7,983				7,521

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