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Note 4 - Balance Sheet Details (Tables)

12 Months Ended

Dec. 31, 2018

Notes Tables

Available-for-sale Securities [Table Text Block]

		December 31, 201 8
						Gross				Gross
		Amortized				Unrealized				Unrealized				Estimated
		Cost				Gains				Losses				Fair Value
U.S. treasury bills and government agency obligations		$	59,747			$	—			$	(6	)		$	59,741
U.S. corporate debt			59,164				—				(77	)			59,087
Foreign corporate debt			5,041				5				—				5,046
U.S. commercial paper			52,800				—				—				52,800
Foreign commercial paper			123,870				—				(9	)			123,861
Total		$	300,622			$	5			$	(92	)		$	300,535

		December 31, 201 7
						Gross				Gross
		Amortized				Unrealized				Unrealized				Estimated
		Cost				Gains				Losses				Fair Value
U.S. corporate debt securities		$	13,003			$	—			$	(10	)		$	12,993
U.S. commercial paper			4,929				—				—				4,929
Foreign commercial paper			9,874				—				—				9,874
Total		$	27,806			$	—			$	(10	)		$	27,796

Schedule of Inventory, Current [Table Text Block]

		December 31,
		2018				2017
Raw materials		$	10,112			$	2,754
Work in process			20,604				4,166
Finished goods			8,316				3,188
Total inventory		$	39,032			$	10,108

Property, Plant and Equipment [Table Text Block]

		December 31,
		2018				2017
Scientific equipment		$	18,077			$	9,742
Leasehold improvements			1,783				1,654
Computer equipment and software			1,190				1,420
Furniture, fixtures and office equipment			1,722				1,024
Property and equipment, gross			22,772				13,840
Less: accumulated depreciation and amortization			(8,095	)			(7,859	)
Property and equipment, net		$	14,677			$	5,981

Schedule of Accrued Liabilities [Table Text Block]

		December 31,
		20 18				2017
Accrued employee salaries and benefits		$	2,330			$	1,292
Accrued bonuses			9,139				5,044
Accrued vacation			1,928				1,438
Accrued expenses for realignment (see Note 7)			—				1,086
Total accrued payroll and employee liabilities		$	13,397			$	8,860

		December 31,
		2018				2017
Accrued product sales allowances		$	25,503			$	9,319
Accrued consulting and professional fees			5,768				6,869
Deferred rent			780				651
Accrued accounts payable			224				148
Other accrued liabilities			440				188
Total other accrued liabilities		$	32,715			$	17,175

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