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Note 5 - Revenue Recognition (Tables)
 12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block]
   
As Reported Under Topic 605
    
Effect of
Change
    
As Adjusted Under Topic 606
  
                         
Inventory
   $
10,108
     $
(198
 )   $
9,910
  
Other accrued liabilities
    
17,175
      
991
      
18,166
  
Deferred revenue
    
2,763
      
(2,763
 )    
—
  
Accumulated deficit
    
(783,455
 )    
1,574
      
(781,881
 )
   
As Reported Under Topic 606
    
Effect of
Change
    
As
Calculated
Under Topic 605
  
                         
Consolidated Balance Sheet as of December 31, 2018:
                        
Inventory
   $
39,032
     $
2,181
     $
41,213
  
Other accrued liabilities
    
32,715
      
(7,195
 )    
25,520
  
Deferred revenue
    
—
      
14,010
      
14,010
  
Accumulated deficit
    
(960,721
 )    
(4,634
 )    
(965,355
 )
                         
Consolidated Statement of Operations for
the Year
Ended
December 31
, 2018
:		                        
Net product sales
   $
77,474
     $
(5,043
 )   $
72,431
  
Cost of product sales
    
27,512
      
(1,983
 )    
25,529
  
Loss from operations
    
(183,937
 )    
(3,060
 )    
(186,997
 )
Net loss
    
(178,840
 )    
(3,060
 )    
(181,900
 )
Basic and diluted net loss per share
    
(2.44
 )    
(0.05
 )    
(2.49
 )
                         
Consolidated Statement of Cash Flows for the
Year
Ended
December 31
, 2018
:		                        
Net loss
   $
(178,840
 )   $
(3,060
 )   $
(181,900
 )
Adjustments to reconcile net loss to net cash used in operating activities:                        
Inventory
    
(29,122
 )    
(1,983
 )    
(31,105
 )
Other accrued liabilities
    
14,941
      
(6,204
 )    
8,737
  
Deferred revenue
    
—
      
11,247
      
11,247
  
Valuation Allowances and Reserves [Table Text Block]
   
Product
Returns
    
Distributor
Fees
    
Discounts,
Rebates and Administrative
Fees
    
Total
  
                                 
Balance at December 31, 2017
   $
521
     $
580
     $
8,218
     $
9,319
  
Provision
    
464
      
7,555
      
58,504
      
66,523
  
Payments/credits
    
(38
 )    
(5,322
 )    
(44,979
 )    
(50,339
 )
Balance at December 31, 2018
   $
947
     $
2,813
     $
21,743
     $
25,503