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Note 10 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Notes Tables

Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]

		December 31,
		2018				2017				2016
Tax at statutory federal rate		$	(37,557	)		$	(67,145	)		$	(58,868	)
State tax, net of federal benefit			(6,527	)			(6,203	)			2,013
Research and development credits			(4,775	)			(5,962	)			(4,206	)
Stock-based compensation expense			(2,059	)			3,151				2,694
Non-deductible compensation			901				—				1,864
Change in valuation allowance			50,834				3,241				55,173
Impact of the 2017 Tax Act			—				74,361				—
Other			(817	)			(1,443	)			1,330
Provision for income taxes		$	—			$	—			$	—

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

		December 31,
		2018				2017
Deferred tax assets:
Net operating loss carryforward		$	172,113			$	134,659
Research and development credits			35,670				25,919
Stock-based compensation			11,905				8,633
Other			3,171				2,920
Total gross deferred tax assets			222,859				172,131
Valuation allowance			(222,859	)			(172,131	)
Net deferred tax assets		$	—			$	—

Summary of Income Tax Contingencies [Table Text Block]

		Year Ended December 31,
		2018				2017				2016
Balance at beginning of year		$	120			$	120			$	120
Additions for tax positions of prior years			—				—				—
Additions based on tax positions related to current year			2,265				—				—
Balance at end of year		$	2,385			$	120			$	120

X

- Definition

Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure for tax positions taken in the tax returns filed or to be filed for which it is more likely than not that the tax position will not be sustained upon examination by taxing authorities and other income tax contingencies. Includes, but is not limited to, interest and penalties, reconciliation of unrecognized tax benefits, unrecognized tax benefits that would affect the effective tax rate, tax years that remain subject to examination by tax jurisdictions, and information about positions for which it is reasonably possible that amounts unrecognized will significantly change within 12 months.

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