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Note 13 - Summary of Quarterly Consolidated Financial Data (Unaudited) (Tables)
 12 Months Ended
Dec. 31, 2018
Notes Tables  
Quarterly Financial Information [Table Text Block]
   
2018
  
   
First
Quarter
    
Second
Quarter
    
Third
Quarter
    
Fourth
Quarter
  
   
(In thousands, except per share amounts)
  
Revenues:
                                
Net product sales
   $
11,567
     $
17,277
     $
19,786
     $
28,844
  
Cost of product sales
    
(3,133
)
    
(5,231
)
    
(7,576
)
    
(11,572
)
Gross Profit
    
8,434
      
12,046
      
12,210
      
17,272
  
Operating expenses:
                                
Research and development
    
39,561
      
30,159
      
30,421
      
39,891
  
General and administrative
    
7,028
      
6,209
      
7,288
      
8,738
  
Sales and marketing
    
13,835
      
14,531
      
16,281
      
19,957
  
Loss from operations
    
(51,990
)
    
(38,853
)
    
(41,780
)
    
(51,314
)
Other income (expense), net
    
(275
)
    
183
      
3,434
      
1,755
  
Net loss
   $
(52,265
)
   $
(38,670
)
   $
(38,346
)
   $
(49,559
)
Basic and diluted net loss per share
   $
(0.81
)
   $
(0.54
)
   $
(0.49
)
   $
(0.63
)
   
2017
  
   
First
Quarter
    
Second
Quarter
    
Third
Quarter
    
Fourth
Quarter
  
   
(In thousands, except per share amounts)
  
Revenues:
                                
Net product sales
   $
3,632
     $
8,510
     $
8,572
     $
10,053
  
Cost of product sales
    
(1,186
)
    
(1,013
)
    
(1,051
)
    
(1,338
)
Gross Profit
    
2,446
      
7,497
      
7,521
      
8,715
  
Operating expenses:
                                
Research and development
    
33,384
      
28,597
      
28,844
      
47,757
  
General and administrative
    
6,742
      
6,185
      
6,462
      
6,165
  
Sales and marketing
    
11,619
      
14,770
      
13,529
      
16,683
  
Loss from operations
    
(49,299
)
    
(42,055
)
    
(41,314
)
    
(61,890
)
Other expense, net
    
(1,030
)
    
(744
)
    
(552
)
    
(600
)
Net loss
   $
(50,329
)
   $
(42,799
)
   $
(41,866
)
   $
(62,490
)
Basic and diluted net loss per share
   $
(1.00
)
   $
(0.80
)
   $
(0.77
)
   $
(1.09
)