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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenues:      
Net product sales $ 77,474 $ 30,767 $ 1,279
Operating expenses:      
Cost of product sales 27,512 4,588 35
Research and development 140,032 138,582 103,125
General and administrative 29,263 25,554 21,366
Sales and marketing 64,604 56,601 47,668
Total operating expenses 261,411 225,325 172,194
Loss from operations (183,937) (194,558) (170,915)
Other income (expense), net:      
Interest income 5,965 1,049 445
Interest expense (2,672) (3,937) (2,664)
Other (expense) income 1,804 (38) (9)
Total other income (expense), net 5,097 (2,926) (2,228)
Net loss (178,840) (197,484) (173,143)
Other comprehensive loss:      
Net unrealized gain on short-term investments (77) 7 23
Comprehensive loss $ (178,917) $ (197,477) $ (173,120)
Basic and diluted net loss per share (in dollars per share) $ (2.44) $ (3.65) $ (4.56)
Shares used in computing basic and diluted net loss per share (in shares) 73,193 54,040 37,925