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Note 5 - Revenue Recognition - Adoption of Topic 606 (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Jan. 01, 2018
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Inventory $ 9,910 $ 39,032       $ 10,108       $ 39,032 $ 10,108  
Other accrued liabilities 18,166 32,715       17,175       32,715 17,175  
Deferred revenue       2,763       2,763  
Accumulated deficit (781,881) (960,721)       (783,455)       (960,721) (783,455)  
Other accrued liabilities 18,166 32,715       17,175       32,715 17,175  
Accumulated deficit (781,881) (960,721)       (783,455)       (960,721) (783,455)  
Net product sales   28,844 $ 19,786 $ 17,277 $ 11,567 10,053 $ 8,572 $ 8,510 $ 3,632 77,474 30,767 $ 1,279
Cost of product sales   11,572 7,576 5,231 3,133 1,338 1,051 1,013 1,186 27,512 4,588 35
Loss from operations                   (183,937) (194,558) (170,915)
Net loss   $ (49,559) $ (38,346) $ (38,670) $ (52,265) $ (62,490) $ (41,866) $ (42,799) $ (50,329) $ (178,840) $ (197,484) $ (173,143)
Basic and diluted net loss per share (in dollars per share)   $ (0.63) $ (0.49) $ (0.54) $ (0.81) $ (1.09) $ (0.77) $ (0.80) $ (1) $ (2.44) $ (3.65) $ (4.56)
Inventory                   $ (29,122) $ (4,768) $ (5,340)
Other accrued liabilities                   14,941 11,482 2,482
Deferred revenue                   $ 1,664 $ 1,099
Calculated under Revenue Guidance in Effect before Topic 606 [Member]                        
Inventory   $ 41,213               41,213    
Other accrued liabilities   25,520               25,520    
Deferred revenue   14,010               14,010    
Accumulated deficit   (965,355)               (965,355)    
Other accrued liabilities   25,520               25,520    
Accumulated deficit   (965,355)               (965,355)    
Net product sales                   72,431    
Cost of product sales                   25,529    
Loss from operations                   (186,997)    
Net loss                   $ (181,900)    
Basic and diluted net loss per share (in dollars per share)                   $ (2.49)    
Inventory                   $ (31,105)    
Other accrued liabilities                   8,737    
Deferred revenue                   11,247    
Accounting Standards Update 2014-09 [Member]                        
Inventory (198)                      
Other accrued liabilities 991                      
Deferred revenue (2,763)                      
Accumulated deficit 1,574                      
Other accrued liabilities 991                      
Accumulated deficit 1,574                      
Net product sales 2,900                      
Cost of product sales $ 200                      
Accounting Standards Update 2014-09 [Member] | Difference between Revenue Guidance in Effect before and after Topic 606 [Member]                        
Inventory   2,181               2,181    
Other accrued liabilities   (7,195)               (7,195)    
Deferred revenue   14,010               14,010    
Accumulated deficit   (4,634)               (4,634)    
Other accrued liabilities   (7,195)               (7,195)    
Accumulated deficit   $ (4,634)               (4,634)    
Net product sales                   (5,043)    
Cost of product sales                   (1,983)    
Loss from operations                   (3,060)    
Net loss                   $ (3,060)    
Basic and diluted net loss per share (in dollars per share)                   $ (0.05)    
Inventory                   $ (1,983)    
Other accrued liabilities                   (6,204)    
Deferred revenue                   $ 11,247