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Note 9 - Stockholders' Equity (Details Textual) - USD ($)
$ / shares in Units, $ in Millions
1 Months Ended 12 Months Ended
Jun. 30, 2018
Apr. 30, 2018
Dec. 31, 2017
Jun. 30, 2017
Jan. 31, 2017
Jun. 30, 2016
May 31, 2015
May 30, 2015
May 31, 2014
Jun. 30, 2011
May 31, 2010
May 31, 2009
Dec. 31, 2007
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Jun. 30, 2014
Proceeds from Issuance of Common Stock $ 194.4 $ 168.7 $ 142.6   $ 163.7                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights                           640,164      
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price                           $ 11.97 $ 8.49 $ 8.37  
Common Stock, Shares, Issued, Total     64,609,000                     78,174,000 64,609,000    
Common Stock, Capital Shares Reserved for Future Issuance                           25,927,688      
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant                           1,354,280      
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period                           10 years      
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period                           4 years      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period                           667,338      
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price                           $ 17.04      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period                           53,521      
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price                           $ 29.71      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term                           5 years 109 days      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value                           $ 31.4 $ 9.9    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value     $ 35.6                     $ 75.7 $ 35.6    
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Outstanding Options, Ending Balance                           15,264,606      
Employee Stock Purchase Plan [Member]                                  
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized       200,000   100,000   100,000 25,000 25,000   10,000 5,000 475,000      
Share-based Compensation Arrangement by Share-based Payment Award Maximum Employee Earnings with held to Purchase Common Stock Percent                           10.00%      
Share-based Compensation Arrangement by Share-based Payment Award Discount on Stock Price                           85.00%      
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period                           71,499 77,283 54,932  
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price                           $ 16.48 $ 12.80 $ 14.03  
Common Stock, Shares, Issued, Total                           279,182      
Common Stock, Capital Shares Reserved for Future Issuance                           195,818      
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Total                           $ 117.5      
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition                           2 years 292 days      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value                           $ 17.24 10.61 11.82  
Share-based Compensation Arrangement by Share-based Payment Award, Per Share Weighted-average Fair Value Price of Shares Purchased     $ 4.51                     $ 9.95 $ 4.51 $ 6.10  
Equity Incentive Plan 2007 [Member]                                  
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized       5,000,000   3,000,000 4,300,000   1,750,000 4,500,000 100,000     18,800,000      
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized                         150,000        
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant                           1,354,280      
Pre-funded Warrants[Member]                                  
Class of Warrant or Right, Number of Securities Called by Warrants or Rights                                 600,000
Class of Warrant or Right, Exercise Price of Warrants or Rights                                 $ 0.01
Class of Warrant or Right, Exercised During Period                             4,426    
Class of Warrant or Right, Outstanding                           595,574      
Common Stock [Member]                                  
Stock Issued During Period, Shares, New Issues 5,100,000 6,900,000 9,700,000   14,100,000                 11,963,000 23,822,000    
Share Price $ 39.50 $ 26 $ 15.50   $ 12.20                   $ 15.50    
Payments of Stock Issuance Costs $ 5.6 $ 10.7 $ 7.4   $ 8.8                        
Stock Issued During Period, Shares, Warrants Exercised                             4,000 2,396,000  
Common Stock [Member] | Pre-funded Warrants[Member]                                  
Stock Issued During Period, Shares, Warrants Exercised                             4,423