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Note 9 - Stockholders' Equity - Common Stock Reserved for Future Issuance (Details) - shares	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Stock options outstanding (in shares)	15,264,606	13,462,963	11,845,376	8,434,988
Stock options available for grant (in shares)	1,354,280
Employee stock purchase plan (in shares)	195,818
Warrants outstanding (in shares)	640,164
Shares of common stock underlying Convertible Notes outstanding (see Note 8) (in shares)	8,472,820
Total shares reserved for future issuance (in shares)	25,927,688

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- Definition

Aggregate number of convertible common shares reserved for future issuance.

+ References

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- Definition

Aggregate number of common shares reserved under employee stock purchase plan for future issuance.

+ References

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- Definition

Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
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Aggregate number of common shares reserved for future issuance.

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
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- Definition

The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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Number of options outstanding, including both vested and non-vested options.

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